活血化瘀类口服中成药治疗急性缺血性脑卒中有效性的网状meta分析

活血化瘀类口服中成药治疗急性缺血性脑卒中有效性的网状meta分析

摘要：急性缺血性脑卒中是一种常见且严重的神经系统疾病，活血化瘀类口服中成药被广泛应用于其治疗。本研究旨在通过网状meta分析评估活血化瘀类口服中成药治疗急性缺血性脑卒中的有效性。我们检索了相关研究，并采用Stata15.0软件对数据进行分析。通过效应图、森林图和演化图的绘制，我们对治疗组和对照组进行整体和亚组分析，以评估活血化瘀类口服中成药在改善患者临床症状、生活质量和神经功能方面的疗效。

结果显示，活血化瘀类口服中成药治疗急性缺血性脑卒中在改善患者临床症状方面具有一定的有效性。整体分析显示，与对照组相比，治疗组的患者在神经功能恢复、肢体活动度改善、言语恢复等方面表现出更好的疗效。亚组分析进一步确认了这一结果。

此外，活血化瘀类口服中成药对改善患者生活质量也具有积极作用。疗效图显示，治疗组的生活质量评分明显优于对照组。亚组分析结果表明，在不同治疗时间、不同用药剂量和不同年龄段的患者中，活血化瘀类口服中成药对改善生活质量均具有显著疗效。

总体而言，活血化瘀类口服中成药治疗急性缺血性脑卒中显示出较好的疗效。但是，本研究也存在一些限制，如研究数量较少、研究样本容量小以及部分研究的质量不高。因此，未来的研究需要进一步加强，以更全面、可靠地评估活血化瘀类口服中成药在治疗急性缺血性脑卒中中的有效性。

关键词：活血化瘀类口服中成药；急性缺血性脑卒中；网状meta分析；有效性

Abstract:Acuteischemicstrokeisacommonandsevereneurologicaldisease,andoraltraditionalChinesemedicine(TCM)withthefunctionofpromotingbloodcirculationandremovingbloodstasisiswidelyusedinitstreatment.ThisstudyaimedtoevaluatetheeffectivenessoforalTCMinthetreatmentofacuteischemicstrokethroughanetworkmeta-analysis.WesearchedforrelevantstudiesandanalyzedthedatausingStata15.0software.Bydrawingeffectmaps,forestplots,andevolutionmaps,weconductedoverallandsubgroupanalysesonthetreatmentgroupandthecontrolgrouptoevaluatetheefficacyoforalTCMinimprovingclinicalsymptoms,qualityoflife,andneurologicalfunctioninpatientswithacuteischemicstroke.

TheresultsshowedthatoralTCMhadacertaineffectivenessinimprovingclinicalsymptomsofpatientswithacuteischemicstroke.Theoverallanalysisshowedthatcomparedwiththecontrolgroup,thetreatmentgrouphadbetteroutcomesintermsofneurologicalfunctionrecovery,improvementinlimbactivity,andspeechrecovery.Subgroupanalysisfurtherconfirmedthisresult.

Inaddition,oralTCMalsohadapositiveeffectonimprovingthequalityoflifeofpatients.Theefficacygraphshowedthatthequalityoflifescoresofthetreatmentgroupweresignificantlyhigherthanthoseofthecontrolgroup.SubgroupanalysisresultsindicatedthatoralTCMhadsignificantefficacyinimprovingqualityoflifeinpatientsatdifferenttreatmenttimes,differentmedicationdoses,anddifferentagegroups.

Inconclusion,oralTCMshowedgoodefficacyinthetreatmentofacuteischemicstroke.However,thisstudyalsohassomelimitations,suchasasmallnumberofstudies,smallsamplesizes,andlowqualityofsomestudies.Therefore,futureresearchneedstobefurtherstrengthenedinordertocomprehensivelyandreliablyevaluatetheeffectivenessoforalTCMinthetreatmentofacuteischemicstroke.

Keywords:oraltraditionalChinesemedicine;acuteischemicstroke;networkmeta-analysis;effectivenesInconclusion,thecurrentevidencesuggeststhatoraltraditionalChinesemedicinehasshownpromisingefficacyinthetreatmentofacuteischemicstroke.However,duetothelimitationsoftheincludedstudies,suchassmallsamplesizesandlowstudyquality,furtherresearchisneededtostrengthentheevidenceandcomprehensivelyevaluatetheeffectivenessoforalTCMinthiscontext.Futurestudiesshouldaimtoincludelargersamplesizesandimprovethequalityof