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淋病变基本诊断模细胞学（皮质区TB淋病变基本诊断模式 淋病变基本诊断模式组织学结构异 淋病变基本诊断模式淋病变基本诊断模式核膜，不规则核 RS Lacunar Popcorn

淋病变基本诊断模式淋病变基本诊断模式淋病变基本诊断模式淋病变基本诊断模式淋病变基本诊断模式 BlastoidBurkkitt‘s（foliiculargrowthpattern）淋病变基本诊断模式淋病变基本诊断模式淋病变基本 Castleman淋病变基本诊断模式骨髓（CLL）或淋（SLL）正常结构破坏，肿瘤细胞淋淋Blastoid WesuggestthatthenodularorfollicularpatternofT-celllymphomaarisesbyspreadoftumorcellsfromthepatentsurroundingperifollicularsinusintothemarginalandmantlezonesofreactivefollicles.淋病变基本诊断模式 淋病变基本诊断模式淋病变基本诊断模式•Largeexpansilefolliclesarescatteredamongusualreactivefollicles,andareseveraltimestheir•Largefolliclescomprisemostlysmall–Admixedisolatedorsmallgroupsofgerminalcentercells–Somemayhavesingleormultipleremnantgerminalcenters(whichcanbequi •NoL&HFollicularlymphoma(floral

淋病变基本诊断模式炎 淋病变基本诊断模式淋病变基本诊断模式HL,NSHL‘‘lacunar淋病变基本诊断模式淋病变基本诊断模式LRHL:LargenodularpatternsimilartoNLPHL;residualGCcanbeseenNodulesandinterfollicularzonemainlycomposedofsmalllymphocytes,withfewsmacellsorRScellsarescatteredwithinandbetweenthenodules.Insomecases,theyarefoundinexpandedmantlezones(so-calledfollicularHL).RScellsareneverfoundingerminalcenters.NodularlymphocytepredominantHL, – ‘Popcorncell’’,alsoknownasL&H(lymphocyticandhistiocyticFollicularlymphoma(floralFollicularlymphoma(floralDifferencesfromAllfolliclesareFeaturestoconfirmMonotonyofcellpopulationingerminalBcl-2immunoreactivityingerminalIglightchainAtypicalpolymorphouswithagranuloma-likeDiagnosis:B-CLLwithRSB-CLL/SLLwithRS-likeInrarecasesofB-CLL/SLL,therearescatteredlargeatypicalRS-likecellswithactivatedBcell,RScellorintermediateimmunophenotypeLargecellsareselectivelyEBV+(EBER+,HowtoreachaMonotonousbackgroundsmalllymphocytes+/-proliferationcentersSmalllymphocytesareBcellswithcoexpressionof+/- T或K细淋病变基本诊断模式LennertLennertLennert T或K细淋病变基本诊断模式CNSLshowacharacteristicgrowthpatternwithanangiocentricinfiltrationandsplittingofbloodvessels.Ingeneralthetumourcellhibitadiffusegrowthpattern;onlyatthetumourbordersthecellsmaybeconfinedtoperivascularspaces.HistopathologicaldetectionofeitheroneoftheseorbothgrowthpatternsdependonthesiteofbiopsywithinthetumouranddonotallowtodiscriminatweendisttsubtypesofPCNSL.case淋病变基本诊断模式淋病变基本诊断模式淋淋 淋病变基本诊断模式 withRS-likeBcellsVeryrare--morelikelytobeseeninScatteredverylargeRS-likecells–B-lineage,EBV+,CanbemistakenforclassicalHodgkinlymphomaorHowtoreachadiagnosis:recognizingtheatypiaofthebackgroundTlymphoidcellscase变变淋病变基本诊断模式淋病变基本诊断模式

淋病变基本诊断模式Oftenyoungage,M>SolitaryenlargedlymphnoderatherthanmattedMostlyinvolvingsuperficialnodes(cervical,inguinal,axillary);almostnevermediastinalOftenstageI/IIdiseaseatpresentationPrognosis：10年率3-5%BcellNLPHL:LymphnodeUsuallytotallyButarimofresidualnodaltissue(withreactivefollicles)canoccurinperiphery;onlyrarelyarereactivefolliclesintima ymixedwiththeneosticThecharacteristicLarge,round,dark-Usuallycloselypacked,sometimesMayappearmottledduetopresenceofMaybesurroundedbyawreathofinnodulesMostlyR-Scellvariants