杏芎氯化钠注射液治疗急性脑梗塞32例临床观察

杏芎氯化钠注射液治疗急性脑梗塞32例临床观察【摘要】目的观察杏芎氯化钠注射液治疗急性脑梗塞的临床疗效。方法将62例急性脑梗塞患者随机分成治疗组和对照组。两组常规治疗方法相同。治疗组给予杏芎氯化钠注射液1次/d，静脉滴注；对照组加丹奥注射液、克林澳注射液2次/d，静脉滴注，脑细胞活化剂特安欣(肌氨肽苷)注射液1次/d，静脉滴注，2周后观察疗效。结果治疗组与对照组的总有效率分别为%和%(),显效率分别为%、%()，均无显着性差异。治疗组在改善神经功能缺损方面明显好于对照组()。结论杏芎氯化钠注射液治疗急性脑梗塞具有多种治疗作用，用药简便、疗效确切，而且在改善神经功能缺损方面作用较好，值得临床推广应用。

【关键词】杏芎氯化钠注射液；急性脑梗塞；临床疗效

Abstract:ObjectiveToobservethetherapeuticeffectofFloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjectiononacutecerebraltwocasesofpatientswithacutecerebralinfarctionweredividedintotwogroupsatrandom,treatmentgroup(32cases)andcontrolgroup(30cases).BothofthegroupsweretreatedwiththesameordinarycasesofthetreatmentgroupweregivenFloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjectionqd,ivgtt.ThecasesofthecontrolgroupweregivensodiumOzagrel,CinepazideMaleateinjection,bid,ivgtt.andMuscularAminoAcidsandPeptidesandNucleosidesInjectiontoobservetheefficacy.Thetreatmentcoursewas2wasnosignificantdifferencebetweentwogroups.Thetotaleffectiverateinthetreatmentgroupandthecontrolgroupwas%and%respectively()andtheexcellenteffectiveratewas%and%respectively().Theneurologicalfunctiondefectscoringinthetreatmentgroupwassignificantlybetterthanthatofinthecontrolgroup().ConclusionBecauseFloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjectioniseasilyusedandhasacocktailpositiveeffectonmanykindsoftreatmentactionandimprovementofneurologicalfunctiondefectinclinic,itisworthbeingpopularizedandusedclinically.

KeywordsFloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjection,Acutecerebralinfarction,Curativeeffect

Cerebralinfarctionisalsocalledischemiabrainstroke,acommonandfrequentcerebrovasculardiseaseinclinic,itisthethirdleadingcauseofdeathinallkindsofdiseaseinmiddle-agedpopulationinclinicwithhighmorbiditymortalityanddisability.Inrecentyearsacutecerebralinfarctionisincreasingtendtoyoung［1］，atpresentnosinglewesternagentcancureiteffectively,butFloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjectioncandoit.Itwillexpandanewtrainofthoughtandopenwidelyfieldofvisionbecauseitcontainsavarietyofmoleculeswithpotentbiologicalactivitiesandacocktailtherapeuticmethodtocureacutecerebralinfarction,butthedrughasn‘tbeenusedforalongperiodoftime,wewillobserveitsefficacyinclinicinordertofurtherinvestigatetherapeuticeffect.

1ClinicalMaterial

Allthecasesweredividedrandomlyintotreatmentgroup(32cases)andcontrolgroup(30cases)from62consecutiveacutecerebralinfarctionpatientsadmittedtoourhospital.Diagnosisofacutecerebralinfarctionforeachcasewasmadeaccordingtostandardofcerebralinfarctiondiagnosisandbraincomputedtomography(CT)and/ormagneticresonanceimages(MRI)wereusedtoconfirmthediagnosis.Patientswithcerebralhemorrhage,liverdisfunction,renaldisfunction,cardiovasculardiseasesandhematologicaldiseaseswereexcluded.

Therewasnosignificantdifferencebetweentwogroupsinages,sexes,symptoms,scoresofneurologicalfunctiondefectandordinarymethodbeforethepatientsadmittedtohospitalbystatisticalanalysis.

StandardofdiagnosisDiagnosisofacutecerebralinfarctionwasmadeaccordingtotheChineseneurologicalacademyaboutessentialsofdiagnosisoneachkindofcerebrovasculardisease［2］.Braincomputedtomography(CT)and/ormagneticresonanceimages(MRI)wereusedtoconfirmthediagnosis.

Tab1Comparisonofgeneralconditionsinthetwogroups

Clinicalsymptomsofacutecerebralinfarctionoftensuddenlytroublestandingorwalking,speakingorunderstanding,seeingwithoneorbotheyesanddizziness,lossofbalanceorcoordination,numbnessoftheface,armorlegweakness,especiallyononesideofthebody,severeheadacheswithnoknowncause,brieflossofconsciousnessoraperiodofdecreasedconsciousness(fainting,confusion,convulsionsorevencoma).

2TherapeuticMethods

Theordinarymethod:thecaseswithhypertensionwasgivenanti-hypertension［3］，withhyperglycemiagivenanti-hyperglycemia,withhighlipidgivenlowingbloodlipid,hydrocephalus,andoxygenation,radiotherapyaccordingtotheconcreteconditionsofacutecerebralinfarction.

ThetreatmentgroupwasgivenFloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjection100～250ml,qd,ivcontrolgroupwasgivensodiumOzagrel160mg,CinepazideMaleate160mginjectionaddto%NaCl,bid,ivgttandMuscularAminoAcidsandPeptidesandNucleosides10mlInjectionqd,ivgtt.Thetreatmentcoursewas2weeks.

Statisticalanalysesweremadeusingthetargetofneurologicalfunctiondefectscorningandclinicalsymptom,forX2test,differenceswithavalueofwereconsideredsignificant.Allthedataweretreatedby

Criterionstandardofefficacy:AllthecaseswerejudgedeffectusingNimoldipinemethodaftertreated2wk,basedon1993MinistryofHeathChina,GuidenceofprincipleofclinicalresearchofnewdrugofChinesetraditionalmedicineonstrokebyscoringtoobservethecomprehensivefunctionofpatientsconsciousness,language,limbs［4］.Eachofscoreis0～4,thefullis28,thefunctiondefectscoringdecreasedmorethan85%isbasicallycure,50%isapparenteffect,20%isameliorate,lessthan20%ordeterioratingtodeathisnoeffectorchange.

Tab2Thetreatmentresult

Theexcellentrate,X2＝，P＞totaleffectiverate,X2＝，P＞，therewasnosignificantdifferencebySPSSX2test,but1patientwasdeadintreatmentgroupmortality%；2patientsweredeadincontrolgroupmortality%.

Tab3neurologicalfunctiondefectscoring

Theneurologicalfunctiondefectscoresaftertherapydecreasedmoreapparentlythanthosethatbeforetherapybothbetweentherapyandcontrolgroupsthroughstatisticaltreatmentttestwithremarkabledifference().

DiscussionChinesemedicalphilosophythinksthatacutecerebralinfarctioncausedbywind-pglegmstaticbloodandimpedimentofvitalenergystagnatingatmainchannel,qivacuitybloodstasis,bothqiandbloodareabsent,organfunctionisoutofcontrol.Itischaracterizedbyitsemphasisonmaintainingandrestoringhomeostasisthroughinteractionwithawidevarietyoftargets.SoChinesetraditionalmedicineandmateriamedicaexpresseitsspecialadvantageandplayimportantrolesonthetreatmentandprevention.FloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjectioncontainsavarietyofmoleculeswithpotentbiologicalactivitiesandmanyactionsuchasanti-thrombosis,thrombolysis,dilatationofbrainvesselsandincreasingofitsbloodflow,improvementofhematology,microcirculation,immunitycerebrovascularinfarctionandscavengingfreeradical,preventionofacutebraininjury,restorationofinjurednerve,inhibitionofplateletaggregation,anti-inflammationreactionandincreaseofthetolerancetoanoxiaandanti-fatigue,promotionofcardio-cerebralcelluarmetabolism,enhancingmemory,andrelievingthesequelforapoplexy.ThelevelsofTNF-α,ET-1significantlydecreasedandNOwereremarkablyhigherinpatientswithcerebralinfarctionwhenitwasusedalone［5］.

Ozagrel,aselectiveremarkableeffectivethromboxaneA2(TXA2)synthetaseinhibitor［6］,antithrombotics,preventstheformationofbloodclotsbypreventingtheaccumulationofplateletsthatformthebasisofbloodclots;CinepazideMaleateacalciumchannelantagonists,dilatebrainbloodvessel,improvemicrocirculationtoincreaseitsbloodflow,MuscularAminoAcidsandPeptidesandNucleosidesanimportantmaterialtotakepartinlifeactivityofhumanbody.

FloiumGinkgoextractandTertramEthypyrazinesodiumchlorideinjectionitselfhasacocktailtherapeuticeffectandisusedconvenientlysoitshouldbepayedenoughattentionbyphysicianforitsadvantageonimprovementofneurologicalfunctiondefectwithacocktailtherapeuticeffecteventhoughthetotaleffectiverateandtheremarkableeffectratehasnosignifican