Mpro-inhibitor-N3-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMproinhibitorN3Cat.No.:HY-136149CASNo.:884650-98-0分⼦式:C₃₅H₄₈N₆O₈分⼦量:680.79作⽤靶点:SARS-CoV;VirusProtease作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:20mg/mL(29.38mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.4689mL7.3444mL14.6888mL5mM0.2938mL1.4689mL2.9378mL10mM0.1469mL0.7344mL1.4689mLBIOLOGICALACTIVITY⽣物活性MproinhibitorN3⼀种有效的SARS-CoV-2MPro抑制剂，EC50值为16.77µM。MproinhibitorN3显⽰出针对HCoV-229E、FIPV和MHV-A59的抗病毒活性[1][2][3]。体外研究MproinhibitorN3(0-100µM)showsantiviralactivitieswithanEC50valueof16.77µMforSARS-CoV-2[1].MproinhibitorN3(0-50µM;14h)inhibitstheviralgrowthwiththeIC50valuesof4,8.8,2.7µMforHCoV-229E,FIPV,IBVandMHV-A59,respectively[2].体内研究MproinhibitorN3(0-0.64µM;3,6h)showsantiviralactivityagainstIBVinchicken,embryos[3].AnimalModel:Chickenembryos[3]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEDosage:0-0.64µMAdministration:3,6hwith100-EID50titerofIBVM41virusResult:ShowedthatN3isabletopenetratecellstoinhibitthereplicationofIBVviruses,probablyatthebeginningofinfection,withthePD50of0.13μmolforthe3-hgroupand0.17μmolforthe6-hgroup.REFERENCES[1].JinZ,etal.StructureofMprofromSARS-CoV-2anddiscoveryofitsinhibitors.Nature.2020Jun;582(7811):289-293.[2].YangH,etal.Designofwide-spectruminhibitorstargetingcoronavirusmainproteases.PLoSBiol.2005Oct;3(10):e324.[3].XueX,etal.Structuresoftwocoronavirusmainproteases:implicationsforsubstratebindingandantiviraldrugdesign.JVirol.2008Mar;82(5):2515-27.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37