hMAO-B-IN-4-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEhMAO-B-IN-4Cat.No.:HY-152671CASNo.:1666119-75-0分⼦式:C₂₀H₁₆O₂S分⼦量:320.4作⽤靶点:MonoamineOxidase作⽤通路:NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:50mg/mL(156.05mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.1211mL15.6055mL31.2110mL5mM0.6242mL3.1211mL6.2422mL10mM0.3121mL1.5605mL3.1211mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(7.80mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性hMAO-B-IN-4(compoundB10)⼀种选择性的、可逆的、可穿透⾎脑屏障(BBB)的⼈单胺氧化-B(hMAO-B)抑制剂，IC50值和Ki值分别为0.067和0.03μM。hMAO-B-IN-4抑制hMAO-A的IC50值为33.82μM。hMAO-B-IN-4可⽤于阿尔兹海默症和帕⾦森⽒病的研究。体外研究hMAO-B-IN-4(0-40μM)showshighselectivitytohMAO-BthanhMAO-AwithaSIvalueof504.791[1].hMAO-B-IN-4(0-40μM)inhibitshMAO-AandhMAO-BwithIC50valuesof33.821and0.067μM,respectively[1].REFERENCES[1].SudevanST,etal.Introductionofbenzyloxypharmacophoreintoaryl/heteroarylchalconemotifsasanewclassofmonoamineoxidaseBinhibitors.SciRep.2022Dec27;12(1):22404.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955