传染病学英文版课件：Rickettsial Diseases

RickettsialDiseasesGeneralintroductionGram-negative,obligateintracellularcoccobacilli

bacteriathatinfectmammaolsandarthropodsRickettsiaearetransmittedinthearthropods,whichservesasbothvectorandreserviorBothDNAandRNAIssensitivetoantibiotic.CategoryofrickettsiaGenusRickettsia,Coxiella,Orientia,EhrlichiaBartonellaSpeciesRickettsiaprowazekii(epidemictyphus),Rickettsiatyphi(endemictyphus),Rickettsiarickettsii(spottedfever),Rochalimaeaquintana(trenchfever),Coxiellaburnetii(Qfever)BilogicalfeaturesVariableshape,coccobacilliGramnegativeMicrocapsuleandslimlayerCulture:inyorksacsofembryonatedeggsReplicationcycleofRickettsiaand

Orientia

AntigenicstructureLPS

RickettsiatsutsugamushiCoxiellaburnetii(Qfever)LPSⅠsmoothLPSⅡroughWeil-FelixreacrionSurfaceprotein(SPA)TransmissionTyphus,spottedfeverandtrenchfeveraretransmittedviaarthropodvectors;Qfeverisacquiredviainhalationoringestionofcontaminatedmilkorfood.PathogenesisVirulencefactors:endotoxin,phospholipaseA,andslimelayerSites:vascularsystemproducingvasculitis血管炎Characteristictriadofsymptoms:fever,headacheandrash(norashwithQfever).Rickettsiaprowazekii

普氏立克次体epidemictyphusaverageincubationperiods(days):8thelouseRespiratorytractandconjunctivaLatentperiod:2weeksAbruptonset,fever,chills,headache,myalgia,arthralgiaRickettsiatyphi

地方性斑疹伤寒立克次体endemictyphus7-14daysMicethelouse&fleaMouth,noseandconjunctivaGradualonset,fever,headache,myalgia,coughRickettsiatsutsugamushi

恙虫病立克次体Tsutsugamushidisease(scrubtyphus)MicetsutsugamushiBlackeachar焦痂Coxiellaburnetti贝纳柯斯体QfeverCowandsheeptickHighresistanceabruptonset,fever,headache,chills,myalgia,granulomatoushepatitischronicdiaeasewithsubacuteonset,endocarditis,hepaticdysfunctionReplicationofC.burnetiiGeneralizedLifeCycleof

DermacentorvariabilisandDermacentorandersoniTicks

Bartonellahenselae汉赛巴通体CSD(catscratchdisease)CatanddogConjunctivainflammationandlymphnodeswellEhrlichia埃里希体属Ehrlichiachaffeensis:humanmonocytotropicehrlichiosisEhrlichiasennetsu:humangranulocytotropicehrlichiosisReplicationofEhrlichia埃里希体ProposedlifecyclefortheagentofHumanGranulocyticEhrlichiosis埃里希体病DiagnosisTheuseofimmunofluorescentantibodiestoexamineabiopsycanbediagnostic.Theorganismcanbeinoculatedintotissuecultureandgrownover4-7daysbutthisisveryhazardoustopersonnel.TheWeil-FelixtestlooksfortheproductionofserumantibodythatisreactiveagainstProteusOX19,OX2orOXKantigensbutitisnotalwaysreliable.ControlSanitary:Arthro