QN523-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEQN523Cat.No.:HY-148255CASNo.:878581-60-3分⼦式:C₁₄H₁₀N₄O分⼦量:250.26作⽤靶点:Apoptosis;Autophagy作⽤通路:Apoptosis;Autophagy储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:≥16.67mg/mL(66.61mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM3.9958mL19.9792mL39.9584mL5mM0.7992mL3.9958mL7.9917mL10mM0.3996mL1.9979mL3.9958mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性QN523⼀种具有类药物性质的新型⽀架，在12种癌细胞株中显⽰出强⼤的体外细胞毒性。QN523诱导细胞凋亡(apoptosis)和⾃噬(autophagy)。QN523可⽤于癌症的研究。体外研究QN523(72h)hascytotoxicitywithIC50valuesrangingfrom0.1to5.7μMacross12celllines[1].QN523(0.1and0.5μM;24and48h;MIAPaCa-2cells)arrestscellcycleatSphaseanddelaysfor1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEpancreaticcancercellstoentertheG2-Mphase.QN523inducesapoptosisandautophagyofMIAPaCa-2Cells[1].CellCycleAnalysis[1]CellLine:MIAPaCa-2cellsConcentration:0.1and0.5μMIncubationTime:24and48hoursResult:DelayedforpancreaticcancercellstoentertheG2-MphasebecauseofaccumulationofcellsintheSphase.ApoptosisAnalysis[1]CellLine:MIAPaCa-2cellsConcentration:0.1and0.5μMIncubationTime:24and48hoursResult:Increasedthenumberofapoptoticcellintime-anddose-dependentmanner.体内研究QN523(10and20mg/kg;i.p.;daily,for44d)inhibitstumorgrowthinmiceofpancreaticcancerxenografts[1].AnimalModel:NOD/SCIDmiceofpancreaticcancerxenografts(6weeksofage)Dosage:10and20mg/kgAdministration:Intraperitonealadministration;1-9days(10mg/kg),10-44days(20mg/kg)Result:Delayedgrowthofthetumors,andnosystemictoxicity.REFERENCES[1].KuangY,et,al.InductionofGenesImplicatedinStressResponseandAutophagybyaNovelQuinolin-8-yl-nicotinamideQN523inPancreaticCancer.JMedChem.2022Apr28;65(8):6133-6156.[2].KuangY,et,al.InductionofGenesImplicatedinStressResponseandAutophagybyaNovelQuinolin-8-yl-nicotinamideQN523inPancreaticCancer.JMedChem.2022Apr28;65(8):6133-6156.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea