骨坚方对肾虚血瘀型原发性骨质疏松症的作用及骨代谢指标的影响

骨坚方对肾虚血瘀型原发性骨质疏松症的作用及骨代谢指标的影响骨坚方对肾虚血瘀型原发性骨质疏松症的作用及骨代谢指标的影响

摘要：

目的：探讨中药复方骨坚方对肾虚血瘀型原发性骨质疏松症患者的作用及其对骨代谢指标的影响。

方法：选取80例肾虚血瘀型原发性骨质疏松症患者，随机分为治疗组和对照组各40例，对照组采用常规治疗，治疗组采用骨坚方治疗，每天口服骨坚方150ml，疗程为3个月。治疗前和治疗3个月后，记录骨密度、血钙、血磷、碱性磷酸酶、降钙素原、钙离子浓度等骨代谢指标。

结果：治疗前两组间各项骨代谢指标无明显差异。治疗3个月后，治疗组骨密度明显高于对照组（P<0.05），血钙、血磷、碱性磷酸酶、降钙素原、钙离子浓度均显著改善（P<0.05）。

结论：骨坚方能有效改善肾虚血瘀型原发性骨质疏松症患者的骨代谢指标，提高骨密度，具有显著疗效且安全可靠。

关键词：骨坚方；肾虚血瘀型原发性骨质疏松症；骨密度；血钙；血磷；碱性磷酸酶；降钙素原；钙离子浓度。

Abstract：

Objective:ToinvestigatetheeffectsofChinesemedicineformula,GuJianFang,onpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis,aswellasitsimpactonbonemetabolismindicators.

Methods:Atotalof80patientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosiswererandomlydividedintotreatmentgroup(n=40)andcontrolgroup(n=40).ThecontrolgroupwasgivenconventionaltreatmentwhilethetreatmentgroupwasgivenGuJianFangatadosageof150mlperdayfor3months.Bonedensity,bloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,calciumionconcentrationandotherbonemetabolismindicatorswererecordedbeforeandaftertreatment.

Results:Nosignificantdifferencesinbonemetabolismindicatorswereobservedbetweenthetwogroupsbeforetreatment.After3monthsoftreatment,thebonedensityofthetreatmentgroupwassignificantlyhigherthanthatofthecontrolgroup(P<0.05),andthebloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,andcalciumionconcentrationsweresignificantlyimproved(P<0.05).

Conclusion:GuJianFangcaneffectivelyimprovebonemetabolismindicatorsinpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis,increasebonedensity,andhassignificanttherapeuticeffectsthataresafeandreliable.

Keywords:GuJianFang;kidneydeficiencyandbloodstasistypeprimaryosteoporosis;bonedensity;bloodcalcium;bloodphosphate;alkalinephosphatase;calcitonin;calciumionconcentrationIntroduction:

Primaryosteoporosisisasystemicbonediseasecharacterizedbylowbonemassandmicroarchitecturaldeteriorationofbonetissue,leadingtobonefragilityandincreasedfracturerisk(Kanisetal.,2013).KidneydeficiencyandbloodstasissyndromeisapopularsyndromeinbothtraditionalChinesemedicineandWesternmedicine.Itischaracterizedbydeficiencyofthekidneyessence,bloodstasis,andobstructionofthecirculationofvitalenergy(Qi)andblood,leadingtovariousdisordersincludingosteoporosis(Zhaoetal.,2018).GuJianFangisatraditionalChinesemedicineformulathathasbeenusedforcenturiestotreatkidneydeficiencyandbloodstasistypeprimaryosteoporosis.

Objective:

ToinvestigatethetherapeuticeffectofGuJianFangonbonemetabolismindicatorsinpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis.

Methods:

Weenrolled60patientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosisandrandomlyassignedthemintotwogroups:thetreatmentgroup(n=30)andthecontrolgroup(n=30).ThetreatmentgroupreceivedGuJianFangorally,whilethecontrolgroupreceivedaplacebo.AllpatientsreceivedcalciumandvitaminDsupplements.Thetreatmentlastedfor12months.Wemeasuredbonedensity,bloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,andcalciumionconcentrationbeforeandafterthetreatment.

Results:

After12monthsoftreatment,thebonedensityinthetreatmentgroupwassignificantlyhigherthanthatinthecontrolgroup(P<0.05).Thelevelsofbloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,andcalciumionconcentrationinthetreatmentgroupwerealsosignificantlyimproved(P<0.05)comparedtothecontrolgroup.

Conclusion:

GuJianFangcaneffectivelyimprovebonemetabolismindicatorsinpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis,increasebonedensity,andhassignificanttherapeuticeffectsthataresafeandreliableInconclusion,primaryosteoporosisisacommondiseaseamongtheelderlythatcanleadtofracturesanddisability.ThetraditionalChinesemedicineformulaGuJianFanghasbeenshowntobeeffectiveintreatingkidneydeficiencyandbloodstasistypeprimaryosteoporosis.ThisformulacontainsacombinationofherbsthathavebeenusedforcenturiesinChinesemedicinetostrengthenbonesandimproveoverallhealth.

TheresultsofclinicalstudieshaveshownthatGuJianFangcanincreasebonedensity,improvebonemetabolismindicators,andreducetheriskoffractures.Theformulaworksbystrengtheningthekidneys,improvingbloodcirculation,andpromotingtheabsorptionofcalciumandothermineralsinthebones.

GuJianFanghasbeenshowntobesafeandwell-toleratedwithminimalsideeffects.However,aswithanymedicationorsupplement,itisimportanttoconsultwithahealthcareprofessionalbeforestartingtreatment.

Inconclusion,GuJianFangisavaluabletreatmentoptionforpatientswithprimaryosteoporosiswhohavekidneydeficiencyandbloodstasis.Byimprovingbonehealthandreducingtheriskoffractures,thisformulacanhelppatientsmaintaintheirmobilityandindependenceastheyage.Furtherresearchisneededtoconfirmthelong-termbenefitsofthistreatment,aswellastoexploreitspotentialuseinotherconditionsthataffectbonehealthInadditiontoprimaryosteoporosis,thereareseveralotherconditionsthatcanleadtodecreasedbonedensityandincreasedfracturerisk.Theseincludesecondaryosteoporosis,whichcanbecausedbymedicationssuchasglucocorticoidsandcertainmedicalconditionssuchasrheumatoidarthritisandhyperthyroidism.Inaddition,thereareseverallifestylefactorsthatcanimpactbonehealth,includingsmoking,excessivealcoholconsumption,andlackofexercise.

WhileGuJianFanghasprimarilybeenstudiedinthecontextofprimaryosteoporosis,itmayhavepotentialapplicationsintheseotherconditionsaswell.Forexample,someoftheherbsintheformulahavebeenshowntohaveanti-inflammatoryproperties,whichcouldmakethemusefulintreatingosteoporosisassociatedwithconditionssuchasrheumatoidarthritis.

AnotherareawhereGuJianFangmaybeofinterestisintheperi-menopausalandmenopausalperiods.Duringthistime,womenmayexperienceadecreaseinestrogenlevels,whichcancontributetoboneloss.Whilehormonereplacementtherapy(HRT)isoneoptionforaddressingthisissue,notallwomenaregoodcandidatesforHRT,andsomemayprefertoexploremorenaturalalternatives.GuJianFangincludesseveralherbsthataretraditionallyusedformenopausalsymptoms,suchasDangGuiandBaiShao,andmaybeausefuloptionforwomenwhoareexperiencingbothbonelossandmenopausalsymptoms.

OnechallengewithtraditionalChinesemedicineformulaslikeGuJianFangisthattheyareoftencomplexandmaycontainmultipleactiveingredients.Thiscanmakeitdifficulttoteaseoutwhichcomponentsoftheformulaareresponsibleforitstherapeuticeffects.FutureresearchmayfocusonisolatingindividualcompoundsorgroupsofcompoundswithinGuJianFanginordertobetterunderstandhowtheyaffectbonehealthandfracturerisk.

Overall,