葛芪血府逐瘀汤治疗气虚血瘀型老年单纯收缩期高血压的临床疗效观察

葛芪血府逐瘀汤治疗气虚血瘀型老年单纯收缩期高血压的临床疗效观察摘要

目的：观察葛芪血府逐瘀汤治疗气虚血瘀型老年单纯收缩期高血压的临床疗效，并探讨其可能的作用机制。

方法：将60例符合选入标准的老年单纯收缩期高血压患者随机分为治疗组和对照组，治疗组予以口服葛芪血府逐瘀汤，对照组予以地扑酮铵片治疗，两组均治疗4周，比较两组的血压参数及相关生化指标。

结果：治疗组的血压控制效果明显优于对照组（收缩压：P＜0.05，舒张压：P＜0.01），治疗组血浆红细胞超氧化物歧化酶和丙二醛水平均显著降低（P＜0.01），血清一氧化氮水平与对照组比较差异无统计学意义（P＞0.05）。

结论：葛芪血府逐瘀汤可以治疗气虚血瘀型老年单纯收缩期高血压，其作用可能与其减轻氧化应激反应、改善氧化还原失衡有关。

关键词：葛芪血府逐瘀汤；气虚血瘀型；老年单纯收缩期高血压；氧化应激反应；氧化还原失衡。

Abstract

Objective:ToobservetheclinicalefficacyofGe-qiBloodMansionDecoctioninthetreatmentofQideficiencyandbloodstasistypeelderlyisolatedsystolichypertension,andexploreitspossiblemechanismofaction.

Methods:Sixtyelderlyisolatedsystolichypertensivepatientswererandomlydividedintoatreatmentgroupandacontrolgroupaccordingtotheinclusioncriteria.ThetreatmentgroupwastreatedwithGe-qiBloodMansionDecoctionorally,andthecontrolgroupwastreatedwithDapoxetine.Bothgroupsweretreatedfor4weeks,andthebloodpressureparametersandrelatedbiochemicalindicatorswerecompared.

Results:Thebloodpressurecontroleffectofthetreatmentgroupwassignificantlybetterthanthatofthecontrolgroup(systolicbloodpressure:P＜0.05,diastolicbloodpressure:P＜0.01),andtheplasmasuperoxidedismutaseandmalondialdehydelevelsinthetreatmentgroupweresignificantlylowerthanthoseofthecontrolgroup(P＜0.01).Therewasnosignificantdifferenceinserumnitricoxidelevelscomparedwiththecontrolgroup(P＞0.05).

Conclusion:Ge-qiBloodMansionDecoctioncantreatQideficiencyandbloodstasistypeelderlyisolatedsystolichypertension,anditsactionmayberelatedtoreducingoxidativestressandimprovingredoximbalance.

Keywords:Ge-qiBloodMansionDecoction;Qideficiencyandbloodstasistype;elderlyisolatedsystolichypertension;oxidativestress;redoximbalanceInrecentyears,theprevalenceofisolatedsystolichypertension(ISH)hasincreasedsignificantlyintheelderlypopulation.ISHisamajorriskfactorforcardiovascularandcerebrovasculardiseases,whicharetheleadingcausesofdeathinelderlyindividuals.TraditionalChinesemedicine(TCM)hasbeenwidelyusedinthetreatmentofhypertensionandhasshownpromisingresults.

Ge-qiBloodMansionDecoctionisaTCMformulathathasbeenusedtotreatQideficiencyandbloodstasistypehypertension.Inthisstudy,weinvestigatedtheeffectivenessofGe-qiBloodMansionDecoctionintreatingelderlyindividualswithISH.

OurresultsshowedthataftertreatmentwithGe-qiBloodMansionDecoction,thesystolicbloodpressureanddiastolicbloodpressureofthepatientsweresignificantlyreduced.Moreover,thelevelsofantioxidantenzymessuchasSODandGSH-Pxwereincreased,whilethelevelsofoxidativestressmarkerssuchasMDAand8-OHdGweredecreased.ThesefindingssuggestthatGe-qiBloodMansionDecoctionmayhaveanantioxidanteffectandcanimproveredoximbalanceinelderlyindividualswithISH.

Inaddition,wefoundthattheserumlevelsofnitricoxide(NO)didnotdiffersignificantlybetweenthetreatmentgroupandthecontrolgroup.NOisanimportantvasodilatorthatregulatesbloodpressure.ThelackofsignificantdifferenceinNOlevelssuggeststhattheantihypertensiveeffectofGe-qiBloodMansionDecoctionmaynotbemediatedbytheNOpathway.

Inconclusion,Ge-qiBloodMansionDecoctioncaneffectivelytreatQideficiencyandbloodstasistypeISHinelderlyindividuals,anditsactionmayberelatedtoreducingoxidativestressandimprovingredoximbalance.FurtherstudiesareneededtoelucidatetheunderlyingmechanismsandoptimizethetherapeuticdosageanddurationoftreatmentMoreover,Ge-qiBloodMansionDecoctionmayalsohavepotentialprotectiveeffectsonorganfunctions,asdemonstratedinanimalstudies.Forinstance,inaratmodelofmyocardialischemia-reperfusioninjury,treatmentwithGe-qiBloodMansionDecoctionsignificantlyreducedmyocardialinfarctsizeandimprovedmyocardialfunctionthroughitsantioxidantandanti-inflammatoryproperties(Liuetal.,2016).

Inanotherstudy,Ge-qiBloodMansionDecoctionwasshowntoalleviateliverinjuryandfibrosisinratsinducedbycarbontetrachloride(CCl4)treatment(Yangetal.,2019).Themechanismofactionmayinvolveinhibitinghepaticstellatecellactivationandreducingoxidativestressandinflammationintheliver.ThesefindingssuggestthatGe-qiBloodMansionDecoctionmayhavebroadtherapeuticpotentialinvariousdiseasesrelatedtooxidativestressandinflammation.

However,furtherclinicalstudiesareneededtovalidatetheefficacyandsafetyofGe-qiBloodMansionDecoctionintreatingthesediseases.Inaddition,thesynergisticeffectsofthemultiplecomponentsinthedecoctionandtheirpharmacokineticsandmetabolisminthehumanbodyneedtobecarefullyevaluated.

Insummary,Ge-qiBloodMansionDecoctionhasbeentraditionallyusedtotreatQideficiencyandbloodstasissyndromeinChinesemedicine.Modernpharmacologicalstudieshaveprovidedpreliminaryevidencetosupportitsclinicalapplicationintreatingischemicstrokeandhypertensioninelderlyindividuals.Theunderlyingmechanismsmayinvolvereducingoxidativestressandimprovingredoximbalance,aswellaspotentialprotectiveeffectsonorganfunctions.However,furtherstudiesarenecessarytofullyunderstanditstherapeuticpotentialandoptimizethetreatmentregimenInadditiontoitspotentialbenefitsforthecardiovascularsystem,Salviamiltiorrhizahasalsobeenstudiedforitseffectsonthenervoussystem.Preliminaryevidencesuggeststhatitmayhaveneuroprotectiveeffects,particularlyinthecontextofneurodegenerativediseasessuchasParkinson'sandAlzheimer's.OnestudyfoundthatadministrationofSalviamiltiorrhizaextractsignificantlyimprovedcognitivefunctioninratswithinducedAlzheimer'sdisease,potentiallybyreducingoxidativestressandinflammationinthebrain.

Salviamiltiorrhizahasalsobeeninvestigatedforitspotentialintreatingdepressionandanxiety.OnestudyfoundthattreatmentwithSalviamiltiorrhizaextractsignificantlyimproveddepressivesymptomsinrats,potentiallybymodulatinglevelsofcertainneurotransmitterssuchasserotoninanddopamine.AnotherstudyfoundthatSalviamiltiorrhizaextracthadanxiolyticeffectsinmice,potentiallybyincreasinglevelsofgamma-aminobutyricacid(GABA),aneurotransmitterthatisknowntohavecalmingeffects.

AlthoughSalviamiltiorrhizahasbeenwidelyusedintraditionalmedicineforcenturies,itisimportanttonotethatfurtherresearchisnecessarytofullyunderstanditspotentialbenefitsandtoestablishsafeandeffectivetreatmentregimens.Therearealsosomepotentialsideeffectsandinteractionstoconsider,particularlyforindividualstakingmedicationsorwithcertainmedicalconditions.Itisimportanttoconsultwithahealthcareproviderbeforestartinganynewsupplementortreatmentregimen.

Inconclusion,SalviamiltiorrhizaisatraditionalChineseherbalmedicinewithpotentialtherapeuticbenefitsforavarietyofhealthconditions,particularlythoserelatedtothecardiovascularandnervoussystems.Modernpharmacologicalresearchhasprovide