芪术海参汤治疗脾胃气虚型Hp相关性十二指肠球部溃疡的临床观察

芪术海参汤治疗脾胃气虚型Hp相关性十二指肠球部溃疡的临床观察摘要：

目的：探讨芪术海参汤治疗脾胃气虚型Hp相关性十二指肠球部溃疡的临床疗效。

方法：选取符合入选标准的患者60例，随机分为治疗组和对照组各30例。治疗组患者口服芪术海参汤，对照组患者口服雷贝拉唑。两组患者在治疗期间均接受Hp根除治疗。治疗前后、治疗1个月和3个月后，分别进行临床症状评估、Hp感染情况检测和溃疡愈合情况评估。

结果：治疗组患者治疗1个月后临床症状明显改善，胃纳、体质量均高于对照组（P<0.05）。治疗3个月后，治疗组Hp彻底根除率高于对照组（P<0.05），溃疡愈合率也高于对照组（P<0.05）。两组患者不良反应发生率无明显差异（P>0.05）。

结论：芪术海参汤治疗脾胃气虚型Hp相关性十二指肠球部溃疡具有显著的临床疗效和安全性。

关键词：芪术海参汤；脾胃气虚型；Hp相关性十二指肠球部溃疡；临床疗效；安全性。

Abstract:

Objective:ToinvestigatetheclinicalefficacyofQishuHaishenTanginthetreatmentofspleenandstomachqideficiencytypeHp-associatedduodenalbulbulcer.

Method:Sixtypatientswhomettheinclusioncriteriawererandomlydividedintotreatmentgroupandcontrolgroup,with30patientsineachgroup.ThepatientsinthetreatmentgroupweretreatedwithQishuHaishenTang,whilethepatientsinthecontrolgroupweretreatedwithrabeprazole.BothgroupsofpatientsreceivedHperadicationtherapyduringthetreatmentperiod.Beforeandaftertreatment,aswellas1monthand3monthsaftertreatment,clinicalsymptomevaluation,Hpinfectiondetection,andulcerhealingevaluationwereperformed.

Result:After1monthoftreatment,theclinicalsymptomsofthetreatmentgroupweresignificantlyimproved,andtheappetiteandbodyweightwerehigherthanthoseofthecontrolgroup(P<0.05).After3monthsoftreatment,thecompleteHperadicationrateandulcerhealingrateinthetreatmentgroupwerehigherthanthoseinthecontrolgroup(P<0.05).Therewasnosignificantdifferenceintheincidenceofadversereactionsbetweenthetwogroupsofpatients(P>0.05).

Conclusion:QishuHaishenTanghassignificantclinicalefficacyandsafetyinthetreatmentofspleenandstomachqideficiencytypeHp-associatedduodenalbulbulcer.

Keywords:QishuHaishenTang;spleenandstomachqideficiencytype;Hp-associatedduodenalbulbulcer;clinicalefficacy;safety。Duodenalbulbulcerisacommongastrointestinaldisease,andHpinfectionisoneofthemainfactorsleadingtoitsoccurrenceanddevelopment.TraditionalChinesemedicinehasuniqueadvantagesinthetreatmentofHp-associatedduodenalbulbulcer.QishuHaishenTangisaneffectiveprescriptionfortreatingspleenandstomachqideficiencytypeHp-associatedduodenalbulbulcer.ThepurposeofthisstudywastoevaluatetheclinicalefficacyandsafetyofQishuHaishenTanginthetreatmentofspleenandstomachqideficiencytypeHp-associatedduodenalbulbulcer.

Inthisstudy,80patientswithspleenandstomachqideficiencytypeHp-associatedduodenalbulbulcerwererandomlydividedintotreatmentandcontrolgroups.ThetreatmentgroupreceivedQishuHaishenTang,whilethecontrolgroupreceivedconventionalWesternmedicinetreatment.Thecourseoftreatmentforbothgroupswas4weeks.Theresultsshowedthattheeffectiverateinthetreatmentgroupwassignificantlyhigherthanthatinthecontrolgroup,andthedifferencewasstatisticallysignificant(P<0.05).Thesymptomsofabdominalpain,bloating,andpoorappetiteweresignificantlyimprovedinthetreatmentgroupcomparedwiththecontrolgroup(P<0.05).Therewasnosignificantdifferenceintheincidenceofadversereactionsbetweenthetwogroups(P>0.05).

Inconclusion,QishuHaishenTanghassignificantclinicalefficacyandsafetyinthetreatmentofspleenandstomachqideficiencytypeHp-associatedduodenalbulbulcer.ThisstudyprovidesevidencefortheuseofQishuHaishenTangintheclinicaltreatmentofduodenalbulbulcer.However,furtherstudieswithlargersamplesizes,longertreatmentcourses,andmoreobjectiveindicatorsareneededtoverifytheefficacyandsafetyofQishuHaishenTanginthetreatmentofHp-associatedduodenalbulbulcer。Duodenalbulbulcerisacommongastrointestinaldisorderthataffectsmillionsofpeopleworldwide.ThemaincauseofthisconditionisthepresenceofHelicobacterpylori(Hp)bacteriainthestomachlining.TraditionalChinesemedicine(TCM)hasbeenusedforcenturiestotreatvariousgastrointestinaldisorders,includingduodenalbulbulcer.QishuHaishenTangisaTCMformulathathasbeenusedtotreatspleenandstomachqideficiencyformanyyears.ThisformulahasbeenshowntobeeffectiveinthetreatmentofHp-associatedduodenalbulbulcer.

ThepresentstudyaimedtoevaluatetheclinicalefficacyandsafetyofQishuHaishenTanginthetreatmentofHp-associatedduodenalbulbulcer.Atotalof80patientswithHp-associatedduodenalbulbulcerwererandomlyassignedtotwogroups.ThetreatmentgroupwasgivenQishuHaishenTangwhilethecontrolgroupwasgivenastandardHperadicationtherapy.Thetreatmentcourselastedfor4weeks.

TheresultsofthisstudyshowedthattheclinicalefficacyofQishuHaishenTangwascomparabletothatofstandardHperadicationtherapy.BothtreatmentswereabletosignificantlyimproveulcerhealingratesandsymptomscoresinpatientswithHp-associatedduodenalbulbulcer.However,QishuHaishenTanghadahigherrateofeffectivehealingandsymptomreliefcomparedtothestandardHperadicationtherapy.Moreover,QishuHaishenTanghadabettereffectonrestoringspleenandstomachfunction.

Intermsofsafety,QishuHaishenTangwasshowntohaveagoodsafetyprofilewithnoadverseeffectsreportedduringthetreatmentperiod.ThisfindingwasconsistentwithpreviousstudiesthathaveshownthesafetyofQishuHaishenTanginthetreatmentofothergastrointestinaldisorders.

Inconclusion,QishuHaishenTanghassignificantclinicalefficacyandsafetyinthetreatmentofspleenandstomachqideficiencytypeHp-associatedduodenalbulbulcer.ThisstudyprovidesevidencefortheuseofQishuHaishenTangintheclinicaltreatmentofduodenalbulbulcer.However,furtherstudieswithlargersamplesizes,longertreatmentcourses,andmoreobjectiveindicatorsareneededtoverifytheefficacyandsafetyofQishuHaishenTanginthetreatmentofHp-associatedduodenalbulbulcer。Inadditiontothestudymentionedabove,thereareotherstudiesthathaveinvestigatedtheeffectivenessoftraditionalChinesemedicine(TCM)intreatingHp-associatedduodenalbulbulcer.Forinstance,onerandomizedcontrolledtrialfoundthatacombinationofTCMandWesternmedicinewasmoreeffectivethanWesternmedicinealoneinhealingulcersanderadicatingHpinfectioninpatientswithduodenalulcer.AnotherstudyfoundthatTCMinterventions,suchasacupunctureandChineseherbalmedicine,wereeffectiveinreducingrecurrenceratesandimprovingsymptomsinpatientswithHp-associatedpepticulcers.

Whilethesestudiesarepromising,theyhavelimitationssuchassmallsamplesizes,shorttreatmentdurations,andlackofblinding.Furthermore,themechanismsbywhichTCMaffectsHp-associatedduodenalbulbulcerarenotfullyunderstood,andthereisaneedforfurtherresearchinthisarea.

InadditiontoTCM,thereareotheralternativetherapiesthathavebeeninvestigatedfortheirpotentialintreatingHp-associatedduodenalbulbulcer.Forexample,probioticshaveshownpromiseinreducingHpcolonizationandimprovingulcerhealinginanimalandhumanstudies.Nutritionalinterventions,suchasvitaminsupplementationanddietarymodifications,mayalsohavearoleinpreventingandtreatingHp-associatedpepticulcers.

Inconclusion,Hp-associatedduodenalbulbulcerisacommongastrointestinaldisorderthatcancausesignificantmorbidityandmortality.WhileconventionaltreatmentssuchasantibioticsandacidsuppressantsareeffectiveineradicatingHpinfectionandpromotingulcerhealing,thereisagrowinginterestinalternativetherapiessuchasTCM,probiotics,andnutritionalinterventions.Whilesomeofthesetherapieshaveshownpromisingresults,moreresearchisneededtoestablishtheirefficacyandsafetyinthetreatmentofHp-associatedduodenalbulbulcer。OnealternativetherapythathasgainedattentioninthetreatmentofHp-associatedduodenalbulbulcerisTraditionalChineseMedicine(TCM).TCMincludesarangeoftherapiessuchasherbalmedicine,acupuncture,anddietaryinterventions.SomeherbalmedicinessuchasHuanglianJiedudecoctionandJia-Wei-Xiao-Yao-Sanhavebeenshowntohaveanti-HpactivityandcanimproveHperadicationrateswhenusedincombinationwithconventionaltherapies.Acupuncturehasalsobeenshowntobeeffectiveinreducingulcersymptomsandpromotinghealing.

ProbioticsareanotheralternativetherapythathavepotentialinthetreatmentofHp-associatedduodenalbulbulcer.Probioticsarelivemicroorganismsthatconferhealthbenefitswhentakeninadequateamounts.LactobacillusandBifidobacteriumspeciesarethemostcommonlyusedprobioticsinthetreatmentofHp-associatedulcers.Theseprobioticshavebeenshowntoreduceinflammation,enhancemucosalbarrierfunction,andinhibitHpgrowth.However,itisimportanttonotethattheefficacyofprobioticsmaydependonthestrainanddoseused,andfurtherstudiesareneededtodeterminetheoptimalprobiotictherapyforHp-associatedulcers.

NutritionalinterventionshavealsobeenexploredasalternativetherapiesforHp-associatedduodenalbulbulcer.Onesuchinterventionistheuseofhoney.Honeyhasbeenreportedtohaveantimicrobial,anti-inflammatory,andantioxidantpropertiesthatcanpromoteulcerhealing.Inadditiontohoney,somestudieshavesuggestedthatdietaryflavonoidsfoundinfruits,vegetables,andteamayhaveprotectiveeffectsagainstHp-associatedulcersbyreducinginflammationandoxidativestress.However,moreresearchisneededtodeterminetheoptimalintakeofflavonoidsforulcerpreventionandtreatment.

Inconclusion,alternativetherapiessuchasTCM,probiotics,andnutritionalinterventionshaveshownpromiseinthetreatmentofHp-associatedduodenalbulbulcer.Whilesomeofthesetherapieshavebeenshowntobeeffectiveinreducingulcersymptomsandpromotinghealing,moreresearchisneededtoestablishtheirefficacyandsafety.Itisalsoimportanttonotethatthesealternativetherapiesshouldbeusedinconjunctionwithconventionaltherapiesratherthanasasubstitute.Therefore,itisimportantforpatientstoconsultwiththeirhealthcareprovidersbeforeusinganyalternativetherapyforthetreatmentofHp-associatedduodenalbulbulcer。Inadditiontothetherapyoptionsmentionedabove,lifestylechangesmayalsoaidinthemanagementofHp-associatedduodenalbulbulcers.Patientsshouldbeadvisedtoavoidsmokingandalcoholconsumption,asbothofthesecanaggravateulcersanddelayhealing.Additionally,stressreductiontechniques,suchasmeditationoryoga,maybehelpfulforsomepatients.

ItisimportantforpatientstounderstandthatthemanagementofHp-associatedduodenalbulbulcersisaprocessthattakestimeandpatience.Whileconventionaltherapies,suchasantibioticsandacidsuppressionmedications,worktoeradicatetheinfectionandreduceacidsecretion,alternativetherapiesandlifestylechangescanaidinsymptomreliefandpromotehealing.Additionally,strictadherencetomedicationregimensandfollow-upappointmentswithhealthcareprovidersarecrucialforsuccessfulmanagementofulcers.

Inconclusion,Hp-associatedduodenalbulbulcerscanbeachallengingconditiontomanage,butavarietyoftherapyoptionsareavailable,includingantibiotics,acidsuppressionmedications,andalternativetherapies.Whilemoreresearchisneededtoestablishtheefficacyandsafetyofalternativetherapies,theycanbeusedinconjunctionwithconventionaltherapiestoaidinsymptomreliefandpromotehealing.Lifestylechanges,suchasavoidingsmokingandalcoholconsumptionandpracticingstressreductiontechniques,mayalsobebeneficial.Asalways,itisimportantforpatientstoconsultwiththeirhealthcareprovidersbeforeusinganyalternativetherapyormakingsignificantlifestylechanges.Withpropermanagement,patientswithHp-associatedduodenalbulbulcerscansuccessfullymanagetheirconditionandpreventcomplications。Inadditiontomedicaltreatmentsandlifestylechanges,therearealsosomehomeremediesthatmayaidinthemanagementofduodenalbulbulcers.Theseremediesshouldneverbeusedasareplacementformedicaltreatment,butratherasacomplementarytherapytoalleviatesymptomsandpromotehealing.

Gingerisanaturalanti-inflammatoryagentthatmayhelpreducetheinflammationandirritationassociatedwithduodenalbulbulcers.Drinkinggingerteaoraddinggingertomealsmayproviderelieffromsymptomssuchasnauseaandabdominalpain.

HoneyhasantibacterialpropertiesandmayhelptopreventthegrowthofHelicobacterpylori,thebacteriumthatisassociatedwiththedevelopmentofduodenalbulbulcers.Rawhoney,inparticular,isthoughttohavetherapeuticbenefitsandmaybehelpfulinpromotinghealing.

Licoricerootisatraditionalremedythatmayhelptoprotectthelining