Smurf1-IN-A01-A01-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESmurf1-IN-A01Cat.No.:HY-110195CASNo.:1007647-73-5Synonyms:A01分⼦式:C₂₂H₂₀ClF₃N₄O₃S分⼦量:512.93作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:62.5mg/mL(121.85mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.9496mL9.7479mL19.4958mL5mM0.3899mL1.9496mL3.8992mL10mM0.1950mL0.9748mL1.9496mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.06mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.06mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Smurf1-IN-A01(A01)⼀种泛素连接酶Smad泛素化调节因⼦-1(Smurf1)抑制剂，kd值为3.664nM，Smurf1-IN-A01通过抑制Smurf1介导的Smad1/5降解来提⾼BMP-2的反应性[1]。IC50&TargetKd:3.664nM(Smurf1)[1]户使⽤本产品发表的科研⽂献•BloodAdv.2021Sep24;bloodadvances.2021004572.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].CaoY,etal.SelectivesmallmoleculecompoundsincreaseBMP-2responsivenessbyinhibitingSmurf1-mediatedSmad1/5degradation.SciRep.2014May14;4:4965.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589