Lenacapavir-GS-6207-DataSheet-生命科学试剂-MedChemExpressVIP

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemELenacapavirCat.No.:HY-111964CASNo.:2189684-44-2Synonyms:GS-6207分⼦式:C₃₉H₃₂ClF₁₀N₇O₅S₂分⼦量:968.28作⽤靶点:HIV作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:200mg/mL(206.55mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.0328mL5.1638mL10.3276mL5mM0.2066mL1.0328mL2.0655mL10mM0.1033mL0.5164mL1.0328mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥6.25mg/mL(6.45mM);Clearsolution2.请依序添加每种溶剂：5%DMSO>>40%PEG300>>5%Tween-80>>50%salineSolubility:2.5mg/mL(2.58mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性Lenacapavir(GS-6207)⼀种HIV-1⾐抑制剂。在MT-4细胞中，Lenacapavir具有抗HIV活性，EC50为100pM，在外周⾎单个核细胞中，对23种来⾃不同亚型的HIV-1临床分离株的平均EC50为50pM(20-160pM)[1]。IC50&TargetEC50:100pM(anti-HIV;inMT-4cells)[1]体外研究Lenacapavir(GS-6207)isapotentcapsid-targetinginhibitorofHIVreplication.Lenacapavirshowssub-nanomolarpotencyintargetcells(EC50=23pM),inafull-cycleassay(EC50=25pM)andinproducercells(EC50=439pM).LenacapavirinterfereswithboththeearlyandlatestagesofHIV-1replicationbutexhibitsgreaterpotencyagainsttheearlystage[2].户使⽤本产品发表的科研⽂献•Viruses.2022May31;14(6):1202.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SinghK,etal.GS-CACompounds:First-In-ClassHIV-1CapsidInhibitorsCoveringMultipleGrounds.FrontMicrobiol.2019Jun20;10:1227.[2].JohnOLink,etal.ClinicaltargetingofHIVcapsidproteinwithalong-actingsmallmolecule.Nature.2020Jul1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te