Ceftobiprole-medocaril-sodium-BAL5788-sodium-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECeftobiprolemedocarilsodiumCat.No.:HY-106574ACASNo.:252188-71-9Synonyms:BAL5788sodium分⼦式:C₂₆H₂₅N₈NaO₁₁S₂分⼦量:712.64作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:250mg/mL(350.81mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.4032mL7.0162mL14.0323mL5mM0.2806mL1.4032mL2.8065mL10mM0.1403mL0.7016mL1.4032mLBIOLOGICALACTIVITY⽣物活性Ceftobiprolemedocaril(BAL5788)sodiumCeftobiprole(HY-112579)的胃肠外前药。Ceftobiprole⼀种⾮肠道吡咯烷酮头孢素。Ceftobiprole⼀种⼴谱头孢素，对甲氧西林(MRSA)和耐万古霉素葡萄球(VRSA)和耐霉素链球具有⾼⽔平的体外活性。Ceftobiprole也抑制⾰兰⽒阳性和⾰兰⽒性病原体。体内研究Ceftobiprolemedocaril(s.c.;3×q12h;totaldailydosesofBAL9141equivalents,2.1,4.2,or8.4mg/kg)causesten-daycumulativesurvivalratesrangedfrom57to100%forfemaleSwissalbinomice(bodyweight,20to22g)infectedPenrCrosCtxsstrainP-15986[1].Ceftobiprolemedocaril(10,40,160mg/kg;singledose;sc)hasT1/2sfrom20minto31min,asthedoserosefrom40mg/kgto160mg/kg.TheAUC/dosevaluesfortheescalatingsingledosesrangesfrom0.585to1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE1.33,andtheCmax/dosevaluesdecreasesfrom1.08to0.90inneutropenicthigh-infectedmice[2].REFERENCES[1].EAzoulay-Dupuis,etal.EfficacyofBAL5788,aprodrugofcephalosporinBAL9141,inamousemodelofacutepneumococcalpneumonia.AntimicrobAgentsChemother.2004Apr;48(4):1105-11.[2].WACraig,etal.Invivopharmacodynamicsofceftobiproleagainstmultiplebacterialpathogensinmurinethighandlunginfectionmodels.AntimicrobAgentsChemother.2008Oct;52(10):3492-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379