BPR1K871-DBPR114-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBPR1K871Cat.No.:HY-100865CASNo.:2443767-35-7Synonyms:DBPR114分⼦式:C₂₅H₂₈ClN₇O₂S分⼦量:526.05作⽤靶点:FLT3作⽤通路:ProteinTyrosineKinase/RTK储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:125mg/mL(237.62mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.9010mL9.5048mL19.0096mL5mM0.3802mL1.9010mL3.8019mL10mM0.1901mL0.9505mL1.9010mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.08mg/mL(3.95mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.95mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性BPR1K871(DBPR114)⼀种⾼效选择性的FLT3/AURKA双重抑制剂，对FLT3和AURKA作⽤的IC50值分别为19nM和22nM。BPR1K871可⽤于癌症的研究[1]。IC50&TargetIC50:19nM(FLT3),22nM(AURKA)[1]体外研究BPR1K871showspotentanti-proliferativeactivitiesinMOLM-13andMV4-11AMLcellswithanEC50of~5nM[1].体内研究BPR1K871isamulti-kinaseinhibitorforthetreatmentofacutemyeloidleukemia(AML)andsolidtumors[1].REFERENCES[1].HsuYC,etal.DiscoveryofBPR1K871,aquinazolinebased,multi-kinaseinhibitorforthetreatmentofAMLandsolidtumors:Rationaldesign,synthesis,invitroandinvivoevaluation.2016Dec27;7(52):86239–86256.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;