骨科植入物局部生命化

骨科植入物局部生命化上海交通大学机械与动力工程学院生物医学制造与生命质量工程研究所骨科植入物的类型脊柱类关节类创伤类CombustorLinerRobotArmAcetabularCupBlastResistantPanel金属3D打印技术标准系列产品多孔钛合金个体化植入物个体化植入物金属3D打印技术开辟了骨科植入技术的新纪元以激光为能量源以电子束为能量源金属3D打印技术金属3D打印技术德国ConceptLaserM2激光熔融成型技术（SelectiveLaserMelting,SLM）瑞典ArcamA1电子束熔化成型技术（ElectronBeamMelting,EBM）高孔隙杆系结构模型，设计孔隙率93.61%八面体嵌套结构模型，设计孔隙率91.48%蜂窝状结构模型，设计孔隙率89.72%孔隙结构设计正六面体嵌套结构模型，设计孔隙率93.53%交叉曲面结构模型，设计孔隙率88.87%正交结构模型，设计孔隙率86.5%材料：不锈钢钛及其合金钴铬钼合金粉体尺寸：45-100μm(EBM)20-30μm(SLM)金属3D打印制造高孔隙杆系结构模型八面体嵌套结构模型蜂窝状结构模型正交结构模型正六面体嵌套结构模型交叉曲面结构模型多孔钛合金结构体孔隙结构特征XiangLi*,etal.Materialsletters2009;63:403-405.XiangLi*,etal.Proc.IMechEPartH:J.EngineeringinMedicine,223:173-178,2009.XiangLi*,etal.RapidPrototypingJournal,16:44-49,2010.EBM技术制造SLM技术制造仿生结构模型孔隙结构特征EBM技术制造SLM技术制造孔隙结构特征孔隙率：66-88%孔的尺寸：415-672μm杆的长度：224±43μm杆的宽度：67-187μmShimkoDA,etal.EffectofPorosityontheFluidFlowCharacteristicsandMechanicalPropertiesofTantalumScaffolds.JBiomedMaterResPartB:ApplBiomater73B:315–324,2005孔隙结构特征多孔钽（Zimmer）力学性能测试多孔钛P（%）65-73Zimmer63-68ActiporeSevillaP,AparicioC,PlanellJA,GilFJ.Comparisonofthemechanicalpropertiesbetweentantalumandnickel–titaniumfoamsimplantmaterialsforboneingrowthapplications.JournalofAlloysandCompounds439(2007)67–73.弹性模量E(GPa)屈服强度σo(MPa)抗压强度σmax(MPa)孔隙率(%)1.7343.655.5851.8654.866.5813.8598.6125.8733.98155.3185.9674.72163.7197.46210-30104-121193-205Corticalbone表面改性多孔钛在SBF模拟体液中浸泡14天SEMmorphologiesofcellsonporoustitaniumsamplesafter14daysofculture.(A–B)pureporoustitaniumscaffoldsand(C–D)poroustitaniumscaffoldswithbiomimeticcoating体外细胞培养Cellviabilityofthesampleover14daysofinvitroculture动物实验植入兔颅骨4、8和12周后取样Histologicalstainingforosteogenesiswithinporoustitaniumafterimplantationfor4,8and12weeks.Ti:pureporousTi,TiC:biomimeticcoatedporousTi4W×168W×1612W×1612W×100TiTiC动物实验HistomorphometricanalysisofnewboneformationXiangLi,etal.EvaluationofBiologicalPropertiesofElectronBeamMeltedTi6Al4VImplantwithBiomimeticCoatinginVitroandInVivo.PLoSONE2012;

7(12):e52049.动物实验利用化学气相沉积法制备钽涂层钽涂层制备方法钽涂层多孔钛体外细胞培养实验多孔钛支架钽涂层支架体外细胞培养实验动物实验Representativehistologicalsectionsofporousimplantsafter12weeksofimplantationinthecristailiacaofgoats.(a–c)Uncoatedand(d–f)Ta-coatedimplants.动物实验ResultsofhistomorphometricalanalysesofuncoatedandTa-coatedXiangLi,etal.TantalumcoatingonporousTi6Al4Vscaffoldusingchemicalvapordepositionandpreliminarybiologicalevaluation.MaterialsScienceandEngineeringC2013;33:2987–2994.与组织工程相结合骨诱导生物材料﹢多孔钛合金﹢干细胞/BMP多孔钛合金承载体组织工程复合多孔支架多孔钛合金支架聚合物海绵优异的力学性能组织亲和性PorousTiSoakedinpolymersolutionTi/polymerconstructPorouscompositescaffoldFreezingLyophilization复合型骨修复体3DPrintingFreeze-dryingGoodMechanicalPropertiesFavorableCellAffinityalginateChitosanChitosan/HAChitosan微观结构XiangLi,YunLuo,ChengtaoWang.PreparationandcharacterizationofporousTi6Al4V/alginatehybridimplantbycombinationofelectronbeammeltingandfreeze-drying.MaterialsLetters,2012;81:23-26.MicrostructureofTi6Al4V/silkfibroincompositescaffold体外细胞培养实验PureTiTi+ChsTi+Chs+HAPureTiTi+ChsTi+Chs+HACellmorphologyonscaffoldsfor7and14days动物实验羊髂骨缺损12周取样动物实验动物实验小结金属3D