ZIKV-IN-3-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEZIKV-IN-3Cat.No.:HY-151446CASNo.:947699-46-9分⼦式:C₃₉H₄₁NO₄分⼦量:587.75作⽤靶点:DNAMethyltransferase;VirusProtease作⽤通路:Epigenetics;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性ZIKV-IN-3(compound5a)⼀种穿⼼莲内酯衍⽣物,有效的ZIKVNS5甲转移酶(MTase)抑制剂，其IC50值为18.34μM。ZIKV-IN-3抑制ZIKV的复制和感染。ZIKV-IN-3可⽤于寨卡病毒(ZIKV)的研究。IC50&TargetIC50:18.34μM(MTase)[1]体外研究ZIKV-IN-2(compound5a;0.08-50μM)inhibitsZIKV-inducedplaqueformationwithanEC50valueof0.76μMandhasanti-ZIKVeffectwithEC50valuesof0.48,0.37,and0.45μMforVero,Huh7andA549cells,respectively[1].ZIKV-IN-2(0.08-50μM;48h)inhibitstheexpressionofZIKVEproteinwithanEC50valueof0.38μMandinhibitsZIKVreplicationandinfection[1].ZIKV-IN-2(0.08-50μM;96h)haslowcytotoxicityinVero,Huh7andA549cells[1].Vero,Huh7andA549cells[1].CellViabilityAssay[1]CellLine:Vero,Huh7andA549cellsConcentration:0.08,0.4,2,10,and50μMIncubationTime:96hoursResult:ExhibitedlowcytotoxicitiestoVerocells,Huh7cellsandA549cellswithCC50>200μMtoallthreecelllines.WesternBlotAnalysis[1]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECellLine:VerocellsConcentration:0.08,0.4,2,10,and50μMIncubationTime:48hoursResult:InhibitedtheexpressionofZIKVEproteininadose-dependentmanner.REFERENCES[1].QianW,etal.DiscoveryofdehydroandrographolidederivativeswithC19hinderedetheraspotentanti-ZIKVagentswithinhibitoryactivitiestoMTaseofZIKVNS5.EurJMedChem.2022Aug27;243:114710.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0