Antimicrobial-agent-9-DataSheet-生命科学试剂-MedChemExpressVIP

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAntimicrobialagent-9Cat.No.:HY-151403分⼦式:C₄₃H₆₂N₁₆分⼦量:803.06作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Antimicrobialagent-9(Compound16)⼀种抗剂(antimicrobial)，对⾰兰⽒阳性和⾰兰⽒性细的MIC范为2-8μg/mL。Antimicrobialagent-9也具有抗炎活性。体外研究Antimicrobialagent-9(Compound16)(0-256μg/mL;18-24h)showsantibacterialactivitywithgeometricmean(GM)valuesoftheMICsof4.5μg/mL[1].Antimicrobialagent-9showsminimumhemolyticconcentration(MHC)of>256μg/mL,thetherapeuticindexis113.8[1].Antimicrobialagent-9(5or20μg/mL;18h)effectivelyinhibitsthereleaseandexpressionofNOandTNF-αfromLPS-stimulatedRAW264.7cells[1].Antimicrobialagent-9isresistanttovariousphysiologicalsalts,humanserum,andproteases[1].Antimicrobialagent-9exhibitssynergisticantimicrobialactivityincombinationwiththreeconventionalantibiotics(Chloramphenicol(HY-B0239),Ciprofloxacin(HY-B0356),andoxacillin)againstMDRPAandMRSA,ispromisingadjuvantsincombinationwithclinicallyusedantibiotics[1].CellViabilityAssay[1]CellLine:E.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917]andS.aureus[KCTC1621]Concentration:0-256μg/mLIncubationTime:18-24hResult:InhibitedbacterialgrowthwithMICsof4,8,4and2μg/mLagainstE.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917]andS.aureus[KCTC1621],1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemErespectively.CellViabilityAssay[1]CellLine:LPS-stimulatedRAW264.7macrophagesConcentration:5μg/mL(forNO/iNOS)and20μg/mL(forTNF-α)IncubationTime:18hResult:EffectivelyinhibitedtheproductionandexpressionofNOandTNF-αfromLPS-stimulatedRAW264.7cells.REFERENCES[1].DineshKumarS,etal.Cationic,amphipathicsmallmoleculesbasedonatriazine-piperazine-triazinescaffoldasanewclassofantimicrobialagents.EurJMedChem.2022Sep8;243:114747.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.