Antifungal-agent-38-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAntifungalagent38Cat.No.:HY-151284分⼦式:C₈H₁₂N₂S₂分⼦量:200.32作⽤靶点:Bacterial;Fungal作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Antifungalagent38⼀种环⼆硫化物，具有抗真和抗细活性。Antifungalagent38能诱导丝收缩，破坏质膜的完整性，造成细胞内容物的破坏和泄漏。体外研究Antifungalagent38(50μg/mL)showsanti-fungalactivityagainst10pathogenicfungiwithinhibitionratesof56.57%(R.solani),100%(S.sclerotiorum),55.09%(B.cinerea),71.23%(F.graminearum),37.32%(M.oryzae),50.87%(P.capsici),100%(A.flavus),59.75%(P.expansum),100%(M.fructicola),65.78%(R.stolonifer),respectively[1].Antifungalagent38(5μg/mL)damagesplasmamembraneintegrityofM.fructicola[1].Antifungalagent38(100μg/mL)displaysexcellentanti-bacterialactivityagainstX.oryzaeaccc11602,X.axonpodis[1].Antifungalagent38inhibitsfungusgrowthwithEC50sof17.09μg/mL(R.solani),6.34μg/mL(S.sclerotiorum),25.24μg/mL(F.graminearum),>10μg/mL(A.flavus),10.42μg/mL(M.fructicola),45.71μg/mL(B.cinerea),respectively[1].CellViabilityAssay[1]CellLine:M.fructicolaConcentration:10,25,50μg/mLIncubationTime:2,4,6daysResult:InhibitedM.fructicolagrowth.体内研究Antifungalagent38(compoundS8)(200μg/mL)displaysequivalentcurativeandhigherprotectiveeffectsas1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEthepositivedrugThiophanate-Methyl(HY-B0842)invivo[1].Antifungalagent38(50,100,200μg/mL,30mL;sprinkling)appliesonpearsandinhibitsM.fructicolagrowthinvivo[1].REFERENCES[1].WangJR,etal.Allicin-InspiredHeterocyclicDisulfidesasNovelAntimicrobialAgents.JAgricFoodChem.2022Sep6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37