Anticancer-agent-32-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAnticanceragent32Cat.No.:HY-143303CASNo.:2222930-76-7分⼦式:C₂₄H₂₁F₂N₅O分⼦量:433.45作⽤靶点:Apoptosis作⽤通路:Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Anticanceragent32(compound2g)⼀种抗癌剂。Anticanceragent32具有抗癌活性，响细胞周期并诱导细胞凋亡。Anticanceragent32可以⽤于癌症的研究。IC50&TargetIC50:17.2μM(MGC-803),12.3μM(HeLa),40.6μM(NCI-H460),46.8μM(HepG2),95.4μM(SMMC-7721),8.9μM(T-24),86.8μM(HL-7702)[1]体外研究Anticanceragent32(2.5-40μM;48h)showscytotoxicactivitiestocancercelllines[1].Anticanceragent32(0-16μM;24h)affectscellcycle,inducescellapoptosis,increasesintracellularlevelsofCa2+andROS[1].CellCytotoxicityAssay[1]CellLine:MGC-803,HeLa,NCI-H460,HepG2,SMMC-7721,T-24andHL-7702celllinesConcentration:2.5,5,10,20and40μMIncubationTime:48hoursResult:InhibitedcellgrowthwithIC50valuesof17.2,12.3,40.6,46.8,95.4,8.9and86.8μMforMGC-803,HeLa,NCI-H460,HepG2,SMMC-7721,T-24andHL-7702cells,respectively.CellCycleAnalysis[1]CellLine:MGC-803andT-24celllinesConcentration:0,8and12μM1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIncubationTime:24hoursResult:SignificantlyinducedcellcyclearrestattheG2/MphaseinT-24cells.WesternBlotAnalysis[1]CellLine:MGC-803andT-24celllinesConcentration:4,8and12μMIncubationTime:24hoursResult:DecreasedexpressionlevelofcyclinB1.ApoptosisAnalysis[1]CellLine:MGC-803andT-24celllinesConcentration:0,4,8and16μMIncubationTime:24hoursResult:InducedcellapoptosisofT-24cellsfrom8.21to32.91%aftertreatmentbyincreasinglevelsofcaspase-3andcaspase-9inT-24cells.REFERENCES[1].LiGZ,etal.Synthesisandbiologicalevaluationofnovel1,3-diphenylureaquinoxalinederivativesaspotentanticanceragents.MedChemRes30,1496–1511(2021).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4