SHMT-IN-2-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESHMT-IN-2Cat.No.:HY-129226CASNo.:2102681-49-0分⼦式:C₂₂H₂₄F₃N₅O分⼦量:431.45作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:100mg/mL(231.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3178mL11.5888mL23.1777mL5mM0.4636mL2.3178mL4.6355mL10mM0.2318mL1.1589mL2.3178mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性SHMT-IN-2⼀种特异性⼈SHMT1/2抑制剂，对SHMT1和SHMT2的IC50值分别为13nM和66nM。SHMT-IN-2可以抑制许多⼈类癌细胞的⽣长，对B细胞淋巴瘤有敏感性。IC50&TargetIC50:2800nM(SHMT1);IC50:36nM(SHMT2)[1]体外研究SHMT-IN-2(compound2)caninhibitcellgrowthwithcellularIC50valuesof2800nMand36nMforSHMT11/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEandSHMT2,respectively[1].SHMT-IN-2(30μM)showsthegrowthsensitivitywiththemedianIC50was4μMtoapanelofnearly300humancancercelllines(withIC50valuesof1.72μMand1.73μMforCCRF-CEMandHT,respectively),celllinesofB-celllymphomaoriginwereenrichedinthemoresensitivehalfofcells[1].REFERENCES[1].regorySDucker,etal.HumanSHMTinhibitorsrevealdefectiveglycineimportasatargetablemetabolicvulnerabilityofdiffuselargeB-celllymphoma.ProcNatlAcadSciUSA.2017Oct24;114(43):11404-11409.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955