IQ-3-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEIQ-3Cat.No.:HY-107600CASNo.:312538-03-7分⼦式:C₂₀H₁₁N₃O₃分⼦量:341.32作⽤靶点:JNK作⽤通路:MAPK/ERKPathway储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:25mg/mL(73.25mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.9298mL14.6490mL29.2980mL5mM0.5860mL2.9298mL5.8596mL10mM0.2930mL1.4649mL2.9298mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性IQ-3特异性的c-JNK家族抑制剂，对JNK3的选择性较好。IQ-3对JNK1、JNK2和JNK3的Kd值分别为0.24μM、0.29μM和0.066μM。IC50&TargetJNK3JNK1JNK2CK1δ0.066μM(Kd)0.24μM(Kd)0.29μM(Kd)0.56μM(Kd)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEPI3KγMKNK20.43μM(Kd)1.2μM(Kd)体外研究IQ-3exhibitsIC50of2.2μM(TNF-αinhumanmonoMac-6cells),1.5μM(IL-6inhumanmonoMac-6cells),4.7μM(TNF-αinhumanPBMCs),9.1μM(IL-6inhumanPBMCs)and6.1μM(NOinmurineJ774.A1),respectively[1].IQ-3exhibitsanIC50of1.4μMforinhibitingLPS-inducedNF-κB/AP-1transcriptionalactivityinhumanTHP-1Bluemonocyticcells[1].IQ-3isindeedacompetitiveinhibitorfortheATPbindingsiteofJNK3[1].CellViabilityAssay[1]CellLine:PBMCs.Concentration:0-80μM(200ng/mLLPS).IncubationTime:30min.Result:DownregulatedTNF-αconcentration(IC50=4.7μM).户使⽤本产品发表的科研⽂献•JEthnopharmacol.2021Aug11;281:114438.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].IgorASchepetkin,etal.Identificationandcharacterizationofanovelclassofc-JunN-terminalkinaseinhibitors.MolPharmacol.2012Jun;81(6):832-45.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;