XY028-140-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEXY028-140Cat.No.:HY-138946CASNo.:2229974-83-6分⼦式:C₃₉H₄₀N₁₀O₇分⼦量:760.8作⽤靶点:CDK;PROTACs作⽤通路:CellCycle/DNADamage;PROTAC储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:5.56mg/mL(7.31mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.3144mL6.5720mL13.1441mL5mM0.2629mL1.3144mL2.6288mL10mM---------请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:0.56mg/mL(0.74mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性XY028-140由Cereblon配体和CDK配体相连的PROTAC。XY028-140抑制癌细胞中的CDK4/6表达和CDK4/6活性。IC50&TargetCDK4CDK6Cereblon体外研究A375melanomaandT47Dbreastcancercellsaretreatedwith0.3or1µΜXY028-140for24hours.XY028-140inhibitsbothCDK4/6expressionandCDK4/6activity[1].T47Dbreastcancercellsaretreatedwith0.03,0.1,0.3,1,or3µΜXY028-140for11days.XY028-140inhibitscancercellproliferationinbreastcancercells[1].REFERENCES[1].JianJin,etal.Compositionsandmethodsfortreatingcdk4/6-mediatedcancer.WO2018106870A1.[2].XueweiWu,etal.DistinctCDK6complexesdeterminetumorcellresponsetoCDK4/6inhibitorsanddegraders.NatCancer2,429-443(2021).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;