SPOP-IN-6b-dihydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESPOP-IN-6bdihydrochlorideCat.No.:HY-122615B分⼦式:C₂₈H₃₄Cl₂N₆O₃分⼦量:573.51作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:41.67mg/mL(72.66mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7436mL8.7182mL17.4365mL5mM0.3487mL1.7436mL3.4873mL10mM0.1744mL0.8718mL1.7436mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(3.63mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性SPOP-IN-6bdihydrochloride⼀种有效的斑型POZ蛋⽩(SPOP)抑制剂，IC50为3.58μM。体外研究SPOP-IN-6bdihydrochlorideshowsIC50sof2-10.2μMforA498,Caki-2,Ketr-3,769-P,0S-RC-2,and786-0cells[1].SPOP-IN-6b(0.1-3.0μM;10hours)dihydrochloridecansuppressSPOPactivity,andthenincreasesuppressioncancersubstrateproteinPTENandDUSP7content[1].体内研究SPOP-IN-6b(40-80mg/kg;intraperitonealinjection;daily;for25days;nudemice)dihydrochloridecanslowdownthegrowthoftumourbysuppressingSPOP[1].户使⽤本产品发表的科研⽂献•MolCell.2020Nov19;80(4):633-647.e7.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GuangcaiY,etal.Thepyrido-pyrimidinesof2-imines-5-ketonegroup-2,5-dihydros-1-H-two.CN107141287A.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;