RS-AMPA-monohydrate-racemic-AMPA-monohydrate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(RS)-AMPAmonohydrateCat.No.:HY-100815DCASNo.:76463-67-7Synonyms:(±)-AMPAmonohydrate分⼦式:C₇H₁₂N₂O₅分⼦量:204.18作⽤靶点:iGluR作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:-20°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性数据体外实验H2O:5mg/mL(24.49mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.8976mL24.4882mL48.9764mL5mM0.9795mL4.8976mL9.7953mL10mM0.4898mL2.4488mL4.8976mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性(RS)-AMPA((±)-AMPA)monohydrate⼀种⾕氨酸类似物，⼀种有效的选择性兴奋性神经递质L-⾕氨酸(L-glutamicacid)激动剂。(RS)-AMPAmonohydrate不会⼲扰海藻酸或NMDA受体的结合位点。体外研究(RS)-AMPAmonohydrate(10-3-10-4M)causesdepolarizationsofculturedratspinalandbrainstemneurones.Thedepolarizationby(RS)-AMPAmonohydrateisclearlydose-dependent,althoughthereisa1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEgreatvariabilityofeffectsbetweenindividualneurones.Applicationof(RS)-AMPAmonohydrateat10-5Mproducesonlysmalldepolarizations(3-7mV),whereasat10-4M,theamplitudesofthedepolarizationsrangedfrom4to33mV.(RS)-AMPAmonohydratealsocausesanincreaseofthedischargerateofspontaneouslyfiringneuronesorsometimesevokedashortburstofactionpotentialsinsilentcells.(RS)-AMPAmonohydrateexertsitsdepolarizingeffectsbyactivatingglutamate/quisqualatereceptorswithoutaffectingNMDAreceptors[1].REFERENCES[1].HösliL,etal.EffectsoftheglutamateanalogueAMPAanditsinteractionwithantagonistsonculturedratspinalandbrainstemneurones.NeurosciLett.1983Mar28;36(1):59-62.[2].SommerB,etal.Flipandflop:acell-specificfunctionalswitchinglutamate-operatedchannelsoftheCNS.Science.1990Sep28;249(4976):1580-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.