Rac-Finerenone-Rac-BAY-94-8862-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(Rac)-FinerenoneCat.No.:HY-111372ACASNo.:1050477-27-4Synonyms:(Rac)-BAY94-8862分⼦式:C₂₁H₂₂N₄O₃分⼦量:378.42作⽤靶点:MineralocorticoidReceptor作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:62.5mg/mL(165.16mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6426mL13.2128mL26.4257mL5mM0.5285mL2.6426mL5.2851mL10mM0.2643mL1.3213mL2.6426mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.08mg/mL(5.50mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(5.50mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.50mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性(Rac)-Finerenone((Rac)-BAY94-8862)Finerenone的外消旋体。Finerenone(BAY94-8862)第三代选择性、具有⼝服活性的、⾮甾体类盐⽪质激素受体(MR)拮抗剂(IC50=18nM)，与糖⽪质激素受体(GR)、雄激素受体(AR)和孕酮受体(AR)相⽐，Finerenone表现出良好的选择性(>500-fold)。REFERENCES[1].BärfackerL,etal.DiscoveryofBAY94-8862:anonsteroidalantagonistofthemineralocorticoidreceptorforthetreatmentofcardiorenaldiseases.ChemMedChem.2012;7(8):1385-1403.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-