Adrenochrome-Adraxone-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAdrenochromeCat.No.:HY-116513CASNo.:54-06-8Synonyms:Adraxone分⼦式:C₉H₉NO₃分⼦量:179.17作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:100mg/mL(558.13mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM5.5813mL27.9065mL55.8129mL5mM1.1163mL5.5813mL11.1626mL10mM0.5581mL2.7906mL5.5813mL体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.5mg/mL(13.95mM);Suspendedsolution;Needultrasonic2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(13.95mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性Adrenochrome(Adraxone)Epinephrine的氧化产物。Adrenochrome⼤⿏⼼脏中⼀种有效的冠状动脉收缩剂。Adrenochrome可⽤于神经系统疾病研究。体外研究Adrenochromedecreasesmicrosomalcalciumbinding,calciumuptakeandCa2+-stimulatedMg2+-dependentATPaseactivities.TheinhibitoryeffectofAdrenochromeonmicrosomalcalciumuptakeactivityoftheisolatedmembraneisindependentofpH(6.0-8.0),calciumconcentrations(10-200μM),proteinconcentration(0.02-0.10mg/mL),temperature(25-37degreesC)andincubationtime(2-30min)[2].体内研究Inisolatedrathearts,concentrationsofAdrenochromefrom1to1000ng/mLincreasescoronarypressureinadose-andtime-dependentmanner.Furthermore,thedegreeofconstrictionbyAdrenochromeisdependentontheCaCl2concentrationintheperfusionmedium[1].REFERENCES[1].MKarmazyn,,etal.Adrenochrome-inducedcoronaryarteryconstrictionintheratheart.JPharmacolExpTher.1981Oct;219(1):225-30.[2].STakeo,etal.Effectsofadrenochromeoncalciumaccumulatingandadenosinetriphosphataseactivitiesoftheratheartmicrosomes.JPharmacolExpTher.1980Sep;214(3):688-93.[3].KojiUeda,etal.Catecholamineoxidation-mediatedtranscriptionalinhibitioninMnneurotoxicity.JToxicolSci.2020;45(10):619-624.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchus