Aurora-kinase-inhibitor-2-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAurorakinaseinhibitor-2Cat.No.:HY-112355CASNo.:331770-21-9分⼦式:C₂₃H₂₀N₄O₃分⼦量:400.43作⽤靶点:AuroraKinase作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:100mg/mL(249.73mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.4973mL12.4866mL24.9732mL5mM0.4995mL2.4973mL4.9946mL10mM0.2497mL1.2487mL2.4973mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(5.19mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.24mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.24mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Aurorakinaseinhibitor-2⼀种选择性和ATP竞争性的Aurora激酶抑制剂，对AuroraA和AuroraB的IC50分别为310nM和240nM。IC50&TargetAuroraAAuroraB310nM(IC50)240nM(IC50)体外研究Aurorakinaseinhibitor-2(Compound1)showsexcellentlevelsofAuroraAenzymeinhibitionandisalsoeffectiveinanMCF7cellularanti-proliferativeassay(IC50valueof1.25µM)[2].REFERENCES[1].AndrewAMortlock,etal.Progressinthedevelopmentofselectiveinhibitorsofaurorakinases.CurrTopMedChem.2005;5(8):807-21.[2].NicolaMHeron,etal.SARandinhibitorcomplexstructuredeterminationofanovelclassofpotentandspecificAurorakinaseinhibitors.BioorgMedChemLett.2006Mar1;16(5):1320-3.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400