2-Aminopurine-DataSheet-生命科学试剂-MedChemExpressVIP

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE2-AminopurineCat.No.:HY-W012642CASNo.:452-06-2分⼦式:C₅H₅N₅分⼦量:135.13作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:5mg/mL(37.00mM;Needultrasonic)H2O:1.35mg/mL(9.99mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM7.4003mL37.0014mL74.0028mL5mM1.4801mL7.4003mL14.8006mL10mM0.7400mL3.7001mL7.4003mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性2-Aminopurine鸟苷和腺苷的荧光类似物，⼀种⼴泛使⽤的于荧光衰变的DNA结构探针。当将2-Aminopurine插⼊寡核苷酸时，其荧光会通过与天然碱堆积⽽被⾼度淬灭。2-Aminopurine已被⽤于探测核酸的结构和动⼒学。体外研究2-Aminopurine(2AP)isnotvaluableasafluorescentlabelbecauseitsfluorescenceishighlyquenchedby1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEstackingwiththenaturalbases,whenitisinsertedinanoligonucleotide.However,itisthisverysusceptibilitytointerbasequenchingthatmakes2APanexquisitelysensitivefluorescentprobeofnucleicacidstructure[1].2-Aminopurinediffersfromadenine(6-aminopurine)onlyinthepositionoftheexocyclicaminegroup,andyetitsfluorescenceintensityisonethousandtimesthatofadenine[1].REFERENCES[1].JMJean,etal.2-Aminopurinefluorescencequenchingandlifetimes:roleofbasestacking.ProcNatlAcadSciUSA.2001Jan2;98(1):37-41.[2].DehongTan,etal.Decreasedglycationandstructuralprotectionpropertiesofγ-glutamyl-S-allyl-cysteinepeptideisolatedfromfreshgarlicscales(AlliumsativumL.).NatProdRes.2015;29(23):2219-22.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;