CDDO-2P-Im-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemECDDO-2P-ImCat.No.:HY-126379CASNo.:1883650-96-1分⼦式:C₃₉H₄₆N₄O₃分⼦量:618.81作⽤靶点:Apoptosis作⽤通路:Apoptosis储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(404.00mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6160mL8.0800mL16.1600mL5mM0.3232mL1.6160mL3.2320mL10mM0.1616mL0.8080mL1.6160mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.36mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性CDDO-2P-ImCDDO咪唑胺类似物，具有化学预防作⽤。CDDO-2P-Im可降低⼩⿏肺癌模型肺肿瘤的⼤⼩和1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE严重程度[1]。体外研究CDDO-2P-Im(100nM;4days)inducesdifferentiationofU937cellsat100nM[1].CDDO-2P-ImsuppressesNOproductioninRAW264.7cellswithanIC50of5.8nM[1].ApoptosisAnalysis[1]CellLine:U937cellsConcentration:30nM,100nMIncubationTime:4daysResult:InduceddifferentiationofU937cellsat100nM.体内研究CDDO-2P-ImismorestablethanCDDO-Iminpharmacokineticstudies[1].CDDO-2P-Imsignificantlyelevateshemeoxygenase-1(HO-1)andquinonereductase(NQO1)mRNAandproteinlevelsinvariousmousetissuesinvivo[1].CDDO-2P-Im(50-200mg/kg;diet;for16weeks)decreasesthenumber,thesizeandtheseverityoftumorsinA/Jmice[1].AnimalModel:Sevenweek-oldfemaleA/Jmice[1]Dosage:50mg/kg,200mg/kgAdministration:Diet;for16weeksResult:Decreasedthenumber,thesizeandtheseverityoftumors.REFERENCES[1].CaoM,etal.NovelsyntheticpyridylanaloguesofCDDO-Imidazolideareusefulnewtoolsincancerprevention.PharmacolRes.2015Oct;100:135-47.[2].CaoM,etal.NovelsyntheticpyridylanaloguesofCDDO-Imidazolideareusefulnewtoolsincancerprevention.PharmacolRes.2015Oct;100:135-47.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.T