宠物内科疾病讲解用药视频-e皮肤病-中文图片

Structure

&Functionof

Normal

Skin冏䐚峚曐岰擿䵦㩮㢁朩TopicsSkin

components峚曐䟲㓟

Role

of

skin峚曐岰㔾孔

Epidermal

structures溔峚擿䵦Hair

follicle

unit切㲬㤷㔯

The

dermis嵋峚PrincipalFeaturesof

CanineSkin壘峚曐岰㷜䴎墥䕣EpidermisDermis嵋峚Connective

tissue擿敀擰擳Follicle

unit切㲬㤷㔯Glands枦㔵Vascular

tissue湬懍擰擳Nervous

tissue徊擻擰擳Sensors䜁濵㱊䅺Panniculusadiposus朮曖柈Coat切Sweat

劃Sebum峚朮Cor

濾獔䈤Proliferation㺀凂

Nutrition橑㝝

Metabolism㓅牎

Immunity㜯寗Skin

surfaceThe

Cutaneous

峚曐䖐姛㹥MicroenvironmentThe

Skin

&Bodily

HealthMegaderm

Inc.25%InputOutputCanine

SEM

dorsal

trunkskin;

freeze

driedCanineSEM

Abdominalskin;freeze

driedCanineSEMAbdominalfollicleinfundibulum;孡箈㆙枥眔切㲬唻䭹㤜freezedriedTraumaticdamage

tocuticular

cellNormal

Canine

HairTrouble

with

Sebum峚朮䓤䐚Structure

ofthe

epidermis溔峚擿䵦Intercellular

lamellaKeratohyalin

granulespromote

aggregationofkeratin㖥瘇濾獔捌暆糲Lamellar

granulelipid

&

enzymes

intercellular

spacesform

outer

layer

ofcornified

cell

envelope

&intercellular

lamellaeimportant

barrier

functionDesmosome云抾Hemidesmosome㤬云抾Structure

of

the

canine

epidermis壘溔峚擿䵦Living

epidermis泟忋蠌癒general

body

surface3-6

cell

layers8-12

mthickStratum

cor

襶賌實general

body

surface儌蹏蠌霆45-52

cell

layers繪肂實12-15

m

thick㥼Paraffinsection

ofhumanepidermiswith‘basket-weave’stratumcor戚敽壢濾獔䈤岰㒜溔峚帟浍㟩塳Cryosectionof

humanepidermis.Methyleneblue

stain㒜溔峚㑼孞㷜㝒䶵梞岰㞒㞝㟩塳Cells

of

the

Epidermis

–1

溔峚岰擲朊-1

Keratinocyte濾獔䕄䟲擲朊––––––Cells

of

the

Epidermis

-2Resident

epidermal

dendritic

cells,䐚肧溔峚岰丽悭壢擲朊–––Other

cells-not

residents-including:㝘㒸擲朊-綊䐚肧Cellular

structure

of

the

epidermisFrom

Lloyd

&

Pa .

BSAVA

Manual

of

Small

Animal

Dermatology.

2nd

Edition,

2002.Epidermal

Dendritic

Cells溔峚丽悭壢擲朊Langerhans’

cellsMelanocytes蓽捌擲朊Melanocyte

in

basal

layertransfers

melanosomes

fromtips

of

dendrites

to

a

group

ofadjacent

keratinocytesNote

spelling

-

s’The

Hair

Follicle

Unit切㲬㤷㔯The

Hair

Follicle

Unit切㲬㤷㔯Simple

hair

follicles-horses,

cattle,man憬㤷切㲬-肘Â墇Â㒜Compound

hair

follicles-cat,dog,sheep㻯㧪切㲬-套Â壘Â攡斶Hairs

&

Coat

Type切㦳㩮滗切抧㵭Coat

type

depends

largely

on滗切抧㵭㐝澭㕿玂Normal

coats-GSD,wildcanidae䐚濰滗切-䖙墓▎矺夃Short

coats帙切Hairs

&

Coat

TypeCoat

density滗切䆨䒈Cats套Growth

rates孋箫癋䒈The

hair

follicle

unit

and

follicular

adnexaeFrom

Lloyd

&

Pa.

BSAVA

Manual

of

Small

Animal

Dermatology.

2nd

Edition,

2002.Structural

components

of

a

hair

follicleFrom

Lloyd

&

Pa .

BSAVA

Manual

of

Small

AnimalDermatology.

2nd

Edition,

2002.HOInnDermauteierr

ralrrootoopatspishehellaathath••••

BCMbleuteolduloowicdlelsais-u-tcphmsepollllisyusd,

inta-t

erno-Hairklooecorrkatm,twinvatriiatishcauhtoxioalairnt,eccudleticalre••

HAtabuxleyoisvtehmd’sisustlaalyl-yer

-1-3••

tClayricortiehnrinelsexemmr&-

caoolrunteifierdroot•

Hckseeherllenlasatein±thyips’ssigat&lmiaoyenhenartir-

1••

CAlayboveuteirc,laenis-utcchmoleranustifeie-d“ntoilerms”a,

lckoevreartinsuisrafatiocenBasementmembrane

zone㷜䑷柈㤜Surrounds

outer

rootsheath㻸㣧㻸乥緄Includes

the

glassymembrane

&

fibrous

rootsheath㣧㨍姧媯柈㩮擐攠乥緄Hair

Growth切㦳孋箫Growth

cycle孋箫㩊䴁–––Modified

by

systemic

factors

&

receptor

status㦹㠒㝊瓗㳂捌㩮㦹㔵壢䗣岰䕓㪯The

hair

cycleFrom

Lloyd

&

Pa .

BSAVAManual

of

Small

AnimalDermatology.

2ndEdition,2002.Specialised

hairs墥冶切㦳Tylotrich㳨㼖切Sinus

(Vibrissae)惒▊瀒级▋Delivery

of

sebum

to

the

epidermis峚朮㧳溔峚岰疿瘭Cryosection

of

bovine

skinHair

follicle

c切㲬懍Sebaceousgland

duct峚朮枦懍Epidermis溔峚SEM

Bovine

skin

surface,

freeze

driedSEM

of

critical

point

dried

bovine

epidermisSEM

of

freeze

dried

canine

skinSkinSurfaceLipidEquine

cryo-SEM

trunk

skinBovine

skinstained

withSudan

&haematoxylin

-Frozen

sectionLipid,

Epidermal

Cells

and

Surface

Damage

朮獔▎溔峚擲朊㩮溔綎䥁㔆

Bovine

skincryosectionshowingether

washedepidermis㐻矆千痳岰墇溔峚㞒㞝㟩塳to

infection㑕Effect

of

cream

on枻岰䡹䜁䶵䬪㡽2

groups

of

mice㐆擰䇱蕌Percentage

lesional

area

calculated

foreach

site燍懃寱㦺綎怛岪㟨刀Effect

of

cream

onto

infectionConclusion:

cream

can

increase

skin

susceptibility

to

infection擿燦◎㑕枻朩䦲脄峚曐岰䯵䜁䘉Frozen

sectionCanine

skin

stained

with

Sudan

&

haematoxylin

-壘峚曐棻㐛㩮棻䴊拪䶵梞-㞝䑔㟩塳Scaling

-

a

keratinisation

problem杝峚-ㄦ忹濾㣸簚组Large

scales

in

the

coatof

an

Irish

setter塝䇶㝒率墥切㦳㆘岰㼉峚䈳The

Adnexal

Glands籰䉀枦㔵Sebaceous峚朮枦Functions㢁朩The

Adnexal

Glands籰䉀枦㔵Sweat劃枦Functions㢁朩Secretory

activity㟨勸卧䘉Sweat

&

sebum

basically

the

same劃㩮峚朮䴎獔崤㧮Sebum峚朮Sweat

Production劃叞岰㠘癌In

Cat,Dog,Cow,Sheep

&

Goat套Â壘Â㽘墇Â攡斶㩮䉓斶In

Cat

footpad,Humans

&

Horses套杆㶍Â㒜㩮肘Bovine

cutaneousmoisturevaporisation

墇峚曐岰櫤㦳咫䒈(McLean,1963)Condensation

of

water

vapour

in

the

coat

of

a

calf

exposed

to

40oC

at

80%RH㴊40䨦刻䒈▎80%崤䇛咫䒈岰墇切㆘岰剠㓟櫤助㞿糲Bovine

sweat

gland

stained

withfluorescent

antibody

to

solublesurface

protein墇劃枦岰榓㜫䡹㔵䶵梞Sweat

containssubstantial

amounts

ofprotein

which

skinsurface

&

can

bedemonstrated

in

thestratum

cor

劃叞㨍䳫㼉矻泷岩峚曐溔綎䑘咫叒濾獔䈤Cryosection

of

bovineepidermis

stained

withSudan

&

haemalum墇溔峚棻㐛㩮棻䴊拪䶵梞Stratum

corCryosection

of

bovineskin

stained

for

IgG墇峚曐IgG䶵梞Cryosection

ofcanine

skin

stainedfor

IgM壘峚曐䇛IgM䶵梞Complement

C3Cryosection

ofcanine

skinstained

for

IgA壘峚曐岰IgA䶵梞IgA

is

present

only

in

the

sweat

glandsIgA㧌㴊劃枦㐏䄺㴊Feline

M.

canisinfection套岰壘䇱䅄䄲槸䜁䶵Destruction

&

fragmentationof

hair

shaft

fomites切䑔䮏滮劍䶵墕Cell

mediated

immunity-e.g.dermatophytosis

擲朊㒭䇞㜯寗-㽤◎岏槸寱Feline

M.

canis

infectionNeutrophils

within

afollicle

surrounding

aninfected

hair切㲬㐏㮾

㐏擲朊㣧㳖䜁䶵切㦳

Dermatophytosis:activation

of

theimmune

response岏槸寱◎嗬卧㜯寗㦯䑶Fungus

has

invadedhairs(cor )嵋槸㖗㝇切㦳▊濾獔▋APCs

acquire

&

processantigen䡹㦁瘾㨪擲朊槣㦸䑘瘾㨪䡹㦁Activation

of

T-helpercells–promote嗬卧T疱㢋擲朊-㖥瘇clonal㜭粲㺀凂proliferationmast

cell

action,mediator

release曑㼉擲朊嗬卧矶䬠㒭獔DTH瘋㦳㵭玱䬱㦯䑶

Phagocytes

releasefungicidal

products㨀㱎擲朊矶䬠嵋槸㒉墕Involvement

ofLangerhans’

cells&keratinocytes?Components

of

the

dermoepidermal

junctionFrom

Lloyd

&

Pa .

BSAVA

Manual

of

Small

Animal

Dermatology.

2nd

Edition,

2002.(7)(4)*(4)*CollagenThe

Dermis嵋峚The

Dermis–1嵋峚-1Thermoregulatory圙爯梮Body

waterstorage㚊䄺瓗㔵剠㓟Majorstructural

component

of

skin峚曐岰㐝澭擿䵦––––SEM:Collagen

fibres

in

the

bovine

dermis墇嵋峚岰朢㦁擐攠Canine

skin

section.Silver

stain

showingcollagen

bundles

&fibres壘峚曐㟩塳◎笢䶵梞岰朢㦁䵁㩮擐攠Canine

skin

section.showing

collagenbundles(blue-green)&elastic

fibres(purple)壘峚曐㟩塳Ã朢㦁䵁▊欉攫梞▋㩮䔛㡽擐攠▊捗梞▋High

power

image

ofcollagen

bundles(blue-green)&elasticfibres(purple)脄㗯箈㆙朢㦁䵁▊欉攫▋㩮䔛