MIF-1-TFA-Pro-Leu-Gly-NH2-TFA-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEMIF-1TFACat.No.:HY-107663ASynonyms:Pro-Leu-Gly-NH2TFA;MelanostatinTFA分⼦式:C₁₅H₂₅F₃N₄O₅分⼦量:398.38作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性数据体外实验DMSO:250mg/mL(627.54mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5102mL12.5508mL25.1017mL5mM0.5020mL2.5102mL5.0203mL10mM0.2510mL1.2551mL2.5102mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.08mg/mL(5.22mM);Suspendedsolution;Needultrasonic2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(5.22mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.22mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性MIF-1TFA⼀种可抑制⿊⾊素合成的抗⽣素，强效抑制StreptomycesbikiniensisNRRLB-1049和B16⿊⾊素瘤细胞的⿊⾊素形成。体外研究MIF-1(Melanostatin,1μM)provokedareversiblehyperpolarizationandasuppressionofspontaneousactionpotentials[2].REFERENCES[1].PRODUCTION,etal.MELANOSTATIN,ANEWMELANINSYNTHESISINHIBITOR.TheJournalofAntibiotics.1991.[2].JAValentijn,etal.Melanostatin(NPY)inhibitedelectricalactivityinfrogmelanotrophsthroughmodulationofK+,Na+andCa2+currents.JPhysiol.1994Mar1;475(2):185-95.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-