MCP110-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEMCP110Cat.No.:HY-123673CASNo.:521310-51-0分⼦式:C₃₃H₃₆N₂O₃分⼦量:508.65作⽤靶点:Ras;Raf作⽤通路:GPCR/GProtein;MAPK/ERKPathway储存⽅式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(491.50mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.9660mL9.8299mL19.6599mL5mM0.3932mL1.9660mL3.9320mL10mM0.1966mL0.9830mL1.9660mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.09mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.09mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性MCP110⼀种Ras/Raf-1相互作⽤的抑制剂。MCP110阻⽌Ras与Raf相互作⽤。MCP110可⽤于⼈类肿瘤的研究[1]。IC50&TargetRasRAF体外研究MCP110(10and20uM)inhibitsH-Ras(V12)-inducedAP-1activationinHEK293cells.RasstimulationofRaf-1activityissignificantlydecreasedbyMCP110(20μM)[1].MCP110(1,2,5,10,and20μM)showsadose-dependentinhibitionofelevatedRaf-1activityinfibrosarcomaHT1080cells[1].MCP110(20μM)decreasescyclinDlevelstimulatedbythetreatmentwithEGF(100ng/mL),platelet-derivedgrowthfactor(20ng/mL),serum,orphorbol12-myristate13-acetate(100nM)inA549cells[1].REFERENCES[1].JuranKato-Stankiewicz,etal.InhibitorsofRas/Raf-1InteractionIdentifiedbyTwo-HybridScreeningRevertRas-dependentTransformationPhenotypesinHumanCancerCells.ProcNatlAcadSciUSA.2002Oct29;99(22):14398-403.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:/r/