Cirazoline-hydrochloride-LD-3098-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemECirazolinehydrochlorideCat.No.:HY-101300CASNo.:40600-13-3Synonyms:LD3098hydrochloride分⼦式:C₁₃H₁₇ClN₂O分⼦量:252.74作⽤靶点:AdenosineReceptor作⽤通路:GPCR/GProtein储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.BIOLOGICALACTIVITY⽣物活性Cirazolinehydrochloride(LD3098hydrochloride)⼀种强有⼒的竞争性α1A肾上腺素受体(α1A-AR)的全激动剂，α1B-AR和α1D-AR的部分激动剂，Ki值分别为120nM，960nM和660nM。体外研究Cirazolinehydrochloride(5-10μM;24hours)doesnotalterGICsurvivalandcounteractedonlypoorlyprazosin‐inducedGICdeath[1].CellViabilityAssay[1]CellLine:Glioblastoma‐initiatingcellsConcentration:5μM;10μMIncubationTime:24hoursResult:DidnoteffectGICcellsurvival.体内研究Cirazolinehydrochloride(drinkingwater;40μM;9month)exhibitssignificantlydecreasedimmobilityintheTSTandenhancesneurogenesisinthemouse[1].AnimalModel:B6/CBAmice[1]Dosage:40μM1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEAdministration:Drinkingwater;40μM;9monthResult:Reversedantidepressant-likephenotypeofCAMα1A-ARMice.REFERENCES[1].DozeVA,etal.alpha(1A)-andalpha(1B)-adrenergicreceptorsdifferentiallymodulateantidepressant-likebehaviorinthemouse.BrainRes.2009Aug18;1285:148-57.[2].SuzanaAssadKahn,etal.TheAnti-HypertensiveDrugPrazosinInhibitsGlioblastomaGrowthviathePKCδ-dependentInhibitionoftheAKTPathway.EMBOMolMed.2016May2;8(5):511-26.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895