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ACUTEMYOCARDIALINFARCTION(AMI)

ACUTEMYOCARDIALINFARCTION(A1DefinitionPrevalence

CauseSymptomsandsignsAuxiliaryexaminations

。Contents

DiagnosisThedifferentialdiagnosiscomplications

Therapy

。DefinitionContentsDiagnosis2DefinitionDeathornecrosisofmyocardialcells.DefinitionDeathornecrosiso3DefinitionFromananatomicormorphologicstandpoint----transmural----nontransmural.DefinitionFromananatomicor4心肌梗死英文课件5DefinitionFromECGfinding--STelevationSTEMI--non-STelevationNSTEMIDefinitionFromECGfinding6PrevalenceTheWorldHealthOrganizationestimatedin2004,that12.2%ofworldwidedeathswerefromischemicheartdisease.PrevalenceTheWorldHealthOr7Leadingcauseofdeathinhigh-ormiddle-incomecountries.

Secondonlyto

lowerrespiratoryinfectionsinlower-incomecountries.Leadingcauseofdeathinhigh8Worldwide,morethan3millionpeoplehaveSTEMIsand4millionhaveNSTEMIsayear.STEMIsoccurabouttwiceasofteninmenaswomen.Worldwide,morethan3million9Ingeneral,MIcanoccuratanyage,butitsincidentriseswithage.Approximately50%ofallMI’sin

theUSoccurinpeopleyoungerthan65yearsofage.Ingeneral,MIcanoccuratany10MortalityThemortalityis50%in24hours.Mortality11CauseCoronaryatherosclerosisFormationofthrombusObstructionofbloodflowMuscledeathincardiacmuscleCauseCoronaryatherosc12Plaquerupture

→adventitialipidcoreCholesterolnuclearthrombosis

Plaquerupture→adventitialipi13Rupturedplaques

Rupturedplaques14Riskfactors

AgeHyperlipidemiaDiabetesmellitusHypertensionSmokingMalegenderFamilyhistoryofatheroscleroticarterialdisease(inheritance)RiskfactorsAge15Inducingfactors

EarlyhoursofthemorningOvereatingHeavyphysicalactivityAgitationRapidriseofbloodpressureDefecatinghardlyShockDehydrationSurgerySeverearrhythmiaInducingfactors

Earlyhours16SymptomsProdromalsymptoms:PainofinfarctionAssociatedsymptomsPainlessinfarctionsuddendeathandEarlyarrhythmiasSymptomsProdromalsymptoms:17Prodromalsymptoms

Occuratrestorwithlessactivitythanusual.Approximatelyonethirdhavehadsymptomsfrom1to4weeksbefore.Prodromalsymptoms

Occuratre18Painofinfarction

AtrestIntheearlymorningSimilartoanginainlocationandradiationbutmoresevere.Nitroglycerinhaslittleeffect,evenopioidmaynotrelievethepain.Painofinfarction

Atrest19Associatedsymptoms

coldsweatweakLight-headednessapprehensivesyncopedyspneaorthopneacoughwheezingnauseaandvomitingabdominalbloatingAssociatedsymptoms

coldsweat20Painlessinfarction

Itisestimatedthatatleast20%ofacuteMIsarepainlessoratypical.ElderlypatientsandpatientswithdiabetesareparticularlypronepainlessoratypicalMI.Painlessinfarction

Itisest21suddendeathandEarlyarrhythmias

About50%occurbeforethepatientsarriveatthehospitals,withdeathpresumablycausedbyventricularfibrillation.suddendeathandEarlyarrhyth22SignsgeneralChestHeartExtremitiesSignsgeneral23Signs

GeneralAnxiousSweatingprofuselybradycardiaortachycardiaLowcardiacoutputArrhythmiaHighorlowbloodpressureRespiratorydistressFeverSignsGeneral24SignsChestRale(pulmonaryedema)

KillipclassificationClassI=absenceofRalesClassII=less50%ofthelungfieldsClassIII=over50%ofthelungfieldsClassIV=cardiogenicshock(rales,hypotension,andsignsofhypoperfusion)SignsChest25SignsHeartAbnormallylocatedventricularimpulse

dyskineticinfractedJugularvenousdistensionrightatrialhypertensionSoftheartsoundsleftventriculardysfunctionSignsHeart26HeartS4atrialgallopsS3ventriculargallopscardiacinsufficiencymitralregurgitationmurmurpapillarymuscledysfunctionrarelyrupturePericardialfrictionrubsHeart27Signs

ExtremitiesEdemaCyanosisandcoldtemperaturelowoutputPeripheralpulsesSignsExtremities28AuxiliaryexaminationsElectrocadiographyLaboratoryfindingsEchocardiographyAuxiliaryexaminationsElectro29ElectrocadiogramECGchanges:STsegmentelevationQwavedevelopmentTwaveinversionElectrocadiogramECGchanges:30STsegmentelevationSTsegmentelevation31心肌梗死英文课件32

33QwavedevelopmentQwavedevelopment34Twaveinversion

Twaveinversion

35Location

Inferiorwall——ⅡⅢaVFAnteriorwall——V1-6Anteroseptalwall——V1-3Apicalorlateralwall—V4-6Posteriorwall-----V7-9

Right-sided

----V4R-V5RLocationInferiorwall——ⅡⅢ36LaboratoryfindingsMarkerTimetoappearanceDurationofelevation6hr12hrSpecificityTroponinI2-6hr5-10d75%90%-100%98%TroponinT2-6hr5-14d80%95%-100%95%CK-MB3-6hr2-4d65%95%95%myoglobin1-2hr<1d85%90%80%LaboratoryfindingsMarkerTi37心肌梗死英文课件38EchocardiographyBedsideassessmentofleftventricularglobalandregionalfunction.Diagnosingpostinfarction,mitralregurgitationorventricularseptaldefect.EchocardiographyBedsideassess39

40WHODefinitionOfMITypicalsymptomsofchestpain≥30minutes

CharacteristicriseandfallofserumenzymelevelsTypicalECGchangeswithdevelopmentofSTelevationorQwavesDiagnosisWHODefinitionOfMITypicalsy41ChestpainHistory、examinationandECGAcutecoronarysyndrome(ACS)STsegmentelevation

Non-STsegmentelevation

NSTEMIUANoTnI(TnT)STEMITnI(TnT)TnI(TnT)ChestpainHistory、examinati42Thedifferentialdiagnosis

AnginaAcutepericarditisAcutepulmonaryembolismAcuteabdominalpainAorticdissectionThedifferentialdiagnosis

An43Complications

DysfunctionorruptureofpapillarymuscleRuptureoftheheartEmbolismCardiacaneurysmPostinfarctionsyndromeComplications

Dysfunctionor44TherapyGeneraltreamentmeasuresControlofcardiacpainRecanalizationtherapyControlofarrhythmias

ControlofshockControlofheartfailureOthertherapiesTherapiesofcomplicationsTherapyGeneraltreamentmeasu45Prevention

Aaspirin

anti-anginaltherapy

Bbeta-blocker

bloodpressurecontrol

Ccholesterollowing

cigarettesquiting

Ddietcontrol

diabetestreatment

Eeducation

exercisePreventionAaspirin46

ThankYouThankYou47DefinitionDeathornecrosisofmyocardialcells.DefinitionDeathornecrosiso48DefinitionFromananatomicormorphologicstandpoint----transmural----nontransmural.DefinitionFromananatomicor49心肌梗死英文课件50Worldwide,morethan3millionpeoplehaveSTEMIsand4millionhaveNSTEMIsayear.STEMIsoccurabouttwiceasofteninmenaswomen.Worldwide,morethan3million51MortalityThemortalityis50%in24hours.Mortality52Painlessinfarction

Itisestimatedthatatleast20%ofacuteMIsarepainlessoratypical.ElderlypatientsandpatientswithdiabetesareparticularlypronepainlessoratypicalMI.Painlessinfarction

Itisest53SignsHeartAbnormallylocatedventricularimpulse

dyskineticinfractedJugularvenousdistensionrightatrialhypertensionSoftheartsoundsleftventriculardysfunctionSignsHeart54WHODefinitionOfMITypicalsymptomsofchestpain≥30minutes

CharacteristicriseandfallofserumenzymelevelsTypicalECGchangeswithdevelopmentofSTelevationorQwavesDiagnosisWHODefinitionOfMITypicalsy55ACUTEMYOCARDIALINFARCTION(AMI)

ACUTEMYOCARDIALINFARCTION(A56DefinitionPrevalence

CauseSymptomsandsignsAuxiliaryexaminations

。Contents

DiagnosisThedifferentialdiagnosiscomplications

Therapy

。DefinitionContentsDiagnosis57DefinitionDeathornecrosisofmyocardialcells.DefinitionDeathornecrosiso58DefinitionFromananatomicormorphologicstandpoint----transmural----nontransmural.DefinitionFromananatomicor59心肌梗死英文课件60DefinitionFromECGfinding--STelevationSTEMI--non-STelevationNSTEMIDefinitionFromECGfinding61PrevalenceTheWorldHealthOrganizationestimatedin2004,that12.2%ofworldwidedeathswerefromischemicheartdisease.PrevalenceTheWorldHealthOr62Leadingcauseofdeathinhigh-ormiddle-incomecountries.

Secondonlyto

lowerrespiratoryinfectionsinlower-incomecountries.Leadingcauseofdeathinhigh63Worldwide,morethan3millionpeoplehaveSTEMIsand4millionhaveNSTEMIsayear.STEMIsoccurabouttwiceasofteninmenaswomen.Worldwide,morethan3million64Ingeneral,MIcanoccuratanyage,butitsincidentriseswithage.Approximately50%ofallMI’sin

theUSoccurinpeopleyoungerthan65yearsofage.Ingeneral,MIcanoccuratany65MortalityThemortalityis50%in24hours.Mortality66CauseCoronaryatherosclerosisFormationofthrombusObstructionofbloodflowMuscledeathincardiacmuscleCauseCoronaryatherosc67Plaquerupture

→adventitialipidcoreCholesterolnuclearthrombosis

Plaquerupture→adventitialipi68Rupturedplaques

Rupturedplaques69Riskfactors

AgeHyperlipidemiaDiabetesmellitusHypertensionSmokingMalegenderFamilyhistoryofatheroscleroticarterialdisease(inheritance)RiskfactorsAge70Inducingfactors

EarlyhoursofthemorningOvereatingHeavyphysicalactivityAgitationRapidriseofbloodpressureDefecatinghardlyShockDehydrationSurgerySeverearrhythmiaInducingfactors

Earlyhours71SymptomsProdromalsymptoms:PainofinfarctionAssociatedsymptomsPainlessinfarctionsuddendeathandEarlyarrhythmiasSymptomsProdromalsymptoms:72Prodromalsymptoms

Occuratrestorwithlessactivitythanusual.Approximatelyonethirdhavehadsymptomsfrom1to4weeksbefore.Prodromalsymptoms

Occuratre73Painofinfarction

AtrestIntheearlymorningSimilartoanginainlocationandradiationbutmoresevere.Nitroglycerinhaslittleeffect,evenopioidmaynotrelievethepain.Painofinfarction

Atrest74Associatedsymptoms

coldsweatweakLight-headednessapprehensivesyncopedyspneaorthopneacoughwheezingnauseaandvomitingabdominalbloatingAssociatedsymptoms

coldsweat75Painlessinfarction

Itisestimatedthatatleast20%ofacuteMIsarepainlessoratypical.ElderlypatientsandpatientswithdiabetesareparticularlypronepainlessoratypicalMI.Painlessinfarction

Itisest76suddendeathandEarlyarrhythmias

About50%occurbeforethepatientsarriveatthehospitals,withdeathpresumablycausedbyventricularfibrillation.suddendeathandEarlyarrhyth77SignsgeneralChestHeartExtremitiesSignsgeneral78Signs

GeneralAnxiousSweatingprofuselybradycardiaortachycardiaLowcardiacoutputArrhythmiaHighorlowbloodpressureRespiratorydistressFeverSignsGeneral79SignsChestRale(pulmonaryedema)

KillipclassificationClassI=absenceofRalesClassII=less50%ofthelungfieldsClassIII=over50%ofthelungfieldsClassIV=cardiogenicshock(rales,hypotension,andsignsofhypoperfusion)SignsChest80SignsHeartAbnormallylocatedventricularimpulse

dyskineticinfractedJugularvenousdistensionrightatrialhypertensionSoftheartsoundsleftventriculardysfunctionSignsHeart81HeartS4atrialgallopsS3ventriculargallopscardiacinsufficiencymitralregurgitationmurmurpapillarymuscledysfunctionrarelyrupturePericardialfrictionrubsHeart82Signs

ExtremitiesEdemaCyanosisandcoldtemperaturelowoutputPeripheralpulsesSignsExtremities83AuxiliaryexaminationsElectrocadiographyLaboratoryfindingsEchocardiographyAuxiliaryexaminationsElectro84ElectrocadiogramECGchanges:STsegmentelevationQwavedevelopmentTwaveinversionElectrocadiogramECGchanges:85STsegmentelevationSTsegmentelevation86心肌梗死英文课件87

88QwavedevelopmentQwavedevelopment89Twaveinversion

Twaveinversion

90Location

Inferiorwall——ⅡⅢaVFAnteriorwall——V1-6Anteroseptalwall——V1-3Apicalorlateralwall—V4-6Posteriorwall-----V7-9

Right-sided

----V4R-V5RLocationInferiorwall——ⅡⅢ91LaboratoryfindingsMarkerTimetoappearanceDurationofelevation6hr12hrSpecificityTroponinI2-6hr5-10d75%90%-100%98%TroponinT2-6hr5-14d80%95%-100%95%CK-MB3-6hr2-4d65%95%95%myoglobin1-2hr<1d85%90%80%LaboratoryfindingsMarkerTi92心肌梗死英文课件93EchocardiographyBedsideassessmentofleftventricularglobalandregionalfunction.Diagnosingpostinfarction,mitralregurgitationorventricularseptaldefect.EchocardiographyBedsideassess94

95WHODefinitionOfMITypicalsymptomsofchestpain≥30minutes

CharacteristicriseandfallofserumenzymelevelsTypicalECGchangeswithdevelopmentofSTelevationorQwavesDiagnosisWHODefinitionOfMITypicalsy96ChestpainHistory、examinationandECGAcutecoronarysyndrome(ACS)STsegmentelevation

Non-STsegmentelevation

NSTEMIUANoTnI(TnT)STEMITnI(TnT)TnI(TnT)ChestpainHistory、examinati97Thedifferentialdiagnosis

AnginaAcutepericarditisAcutepulmonaryembolismAcuteabdominalpainAorticdissectionThedifferentialdiagnosis

An98Complications

DysfunctionorruptureofpapillarymuscleRuptureoftheheartEmbolismCardiacaneurysmPostinfarctionsyndromeComplications

Dysfunctionor99TherapyGeneraltreamentmeasuresControlofcardiacpainRecanalizationtherapyControlofarrhythmias

Cont

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