1-Cyclohexyl-3-dodecyl-urea-CDU-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE1-Cyclohexyl-3-dodecyl ureaCat. No.: HY-135795CAS No.: 402939-18-8Synonyms: CDU; N-Cyclohexyl-N-dodecyl urea; NCND分式: CHNO分量: 310.52作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数

2、据体外实验 Ethanol : 16.67 mg/mL (53.68 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.2204 mL 16.1020 mL 32.2040 mL5 mM 0.6441 mL 3.2204 mL 6.4408 mL10 mM 0.3220 mL 1.6102 mL 3.2204 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为

3、保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% EtOH 90% corn oilSolubility: 1.67 mg/mL (5.38 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND)种具

4、有度选择性的可溶性环氧化物解酶 (sEH) 抑制剂。1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) 可提管紧张素 II (Ang II) 压中的环氧碳三烯酸 (EETs) 平并降低压。IC50 & Target IC50: soluble epoxide hydrolase (sEH) 1体内研究 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day

5、;4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oilvehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals 1.Animal Model: Male Sprague-Dawley rats 1Dosage: 3mg/dayAdministration: Intraperitoneal injection; 4 daysRes

6、ult: Had antihypertensive properties.REFERENCES1. Imig JD,et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.Hypertension. 2002Feb;39(2 Pt 2):690-4.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820