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1、：麦冬作为一种滋阴药，在传统中药中具有重要地位。麦冬的主要化学成分包括多糖、皂甙、高异：麦冬作为一种滋阴药，在传统中药中具有重要地位。麦冬的主要化学成分包括多糖、皂甙、高异Research Progress of the Pharmacological Actions of Ophiopogon Japonicus ：japonicus, adrug whichcouldnourishYin,has ahesoftraditional medicine.The main constituents in Ophiopogon japonicus are polysaccharides，stero

2、id saponins, and isoflavonesThe Ophiopogon japonicus polysaccharide (OJP1) is the main medicinal component. With the constant in-depth study of Ophiopogon japonicus in recent years, its pharmacological activity has beenfound.Thispassage t OJP1 has various medical ch as immune regulation, anti-myocar

3、dial ischemia, anti-hypoxia and anti-allergyand so onthroughthe reviewysis of the onthepharmacologicalactionof OJP1，whichcouldoffersomeforthefurther 中药麦冬是百合科（Liliaceae）多年生草本植物沿阶草属（Ophiopogon Ker Gawl） ，并能促进使胰岛细胞的恢复；提高机体免疫功能8具有抗心律失常的作用；、抗心肌缺血、抗过敏20等方面。本文次就麦冬效也主要集中在免疫活性李成荫1等人通过选取NOD小鼠为干燥综合征疾病模型，观察麦冬多糖

4、对NOD小鼠颌下 韩凤梅2等人对小鼠进行60Co-射线全身照射和注射环磷酰胺韩凤梅2等人对小鼠进行60Co-射线全身照射和注射环磷酰胺，形成免疫损伤模型，对由60Co-射线和环磷酰胺造成的小鼠免损伤有一定的恢复作用，能显著增强免疫苟兴能3等人将小鼠置于放有铁氧体磁体的小鼠笼中饲养，建立磁场模型组，通过磁场 , 增溶血素, , 郑琴5等研究了麦冬多糖(MDG-1)对豚鼠离体心脏缺血再灌注损伤和皮下注射异丙肾 具有一定的保护作用。同时研究6发现另外一种麦冬多糖FOJ-5(相对分子质量为5103- 具有一定的保护作用。同时研究6发现另外一种麦冬多糖FOJ-5(相对分子质量为5103- 徐德生8等采用

5、异丙肾上腺素诱导大鼠心肌坏死的实验方法以ISO造成大鼠心肌坏对于麦冬多糖的抗心肌缺血的作用机制，研究8表明MDG-1可保护人 林晓9等人在对麦冬多糖进行深入研究后发现对于麦冬多糖的抗心肌缺血作用研究已, OJP可以使缺血再灌的大鼠心脏收缩幅度和冠脉流量较快地恢复, 抑制心率加快, .作用, 大 2 2 毛讯11以腹腔注射四氧嘧啶小鼠模型，用生理盐水、二甲双胍和两种不同2 毛讯11以腹腔注射四氧嘧啶小鼠模型，用生理盐水、二甲双胍和两种不同。显抑制血糖升高，其降糖效果随麦冬的产地不同而有差异。何陵湘12选用正常小鼠. 等13以空腹血糖值为指标，观察川麦冬蔗糖后血糖升高时间及降低血糖峰浓度 廖靖等1

6、4以小胰岛素水平及C-反应蛋白含量为观察指标，对链脲佐茵素造 活性，作用机制是通过减少胰岛素抵抗来实现。Ding等16对麦冬多糖机 活性，作用机制是通过减少胰岛素抵抗来实现。Ding等16对麦冬多糖机制进行17Chen等18从麦冬根部中提取分离得到另一水溶性麦冬多糖OJP1，给予OJP1(150、制，研究19表明：1麦冬多糖能够明显的促进脂肪细胞对血糖的转运和利用，从研究发现，麦冬多糖对呼吸系统有较明显作用，具有抗过敏和平喘作用。汤军等20过整体实验, 观察麦冬多糖200、50mg/kg) 皮肤过敏( PCA) 、等21通过对正常组大氧化物含量增加，红细胞免疫功能下降等，导致衰老。皮下注射生理

7、盐水, 并灌服温开水; 等21通过对正常组大氧化物含量增加，红细胞免疫功能下降等，导致衰老。皮下注射生理盐水, 并灌服温开水; 模型组大 灌服温开水; , 许燕萍等22实验证明在大鼠颈总动脉结扎所致脑缺血实验中，结扎前给予麦冬多糖可缺血组织，防止细胞损害。提示麦冬多糖对脑缺血损伤有抗缺氧保护作用。莫正纪等23、，1Li CY,Wang Y,SunLX,Yan TT, TaoYF,WuS LProtectionof OphiopogonJaponicus onsubmandibularglandsinNoDmiceJ.JournalofImmunology, 2014(30):198-2HanF

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