YM-90709 - Interleukin Related 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEYM-90709Cat. No.: HY-19969CAS No.: 163769-88-8分式: CHNO分量: 359.42作靶点: Interleukin Related作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (173.89 mM; Ne

2、ed ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.79 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.79 mM); Suspended solution; Need ultrasonic1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 YM-90709种

3、新型拮抗剂, 抑制IL-5与IL-5受体结合。REFERENCES1. Morokata T, et al. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.Int Immunopharmacol. 2002 Nov;2(12):1693-702.2. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-9

4、0709, on antigen-induced eosinophil infiltration into the airwayof BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5.3. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo7,8indolizino2,3-bquinoxaline), on antigen-induced airway inflammation in BN rats. Int Immunopharmacol. 2004Jul;4(7):873-83.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F