VGX-1027-GIT-27-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEVGX-1027Cat. No.: HY-15507CAS No.: 6501-72-0Synonyms: GIT 27分式: CHNO分量: 205.21作靶点: Interleukin Related作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 56 mg/mL (2

2、72.89 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.8731 mL 24.3653 mL 48.7306 mL5 mM 0.9746 mL 4.8731 mL 9.7461 mL10 mM 0.4873 mL 2.4365 mL 4.8731 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 VGX-1027(GIT27)具有免疫调节活性，能降低巨噬细胞的I

3、L-1，TNF-和IL-10分泌。户使本产品发表的科研献1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE mustansiriya medical journal. 2018 Nov.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Stosic-Grujicic S, et al. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid,

4、 preventsspontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multipl2. Stojanovic I, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation ofcytokine synthesis an

5、d prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immuno3. Mangano K, et al. In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis inmice by the novel immunomodulatory agent VGX-1027. Eur J Pharmacol. 2008 May 31;586(1-3):313-21.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0