EMD638683-S-Form - SGK 抑制剂 - 生命科学试剂 - MedChemExpressVIP

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEMD638683 S-FormCat. No.: HY-15193BCAS No.: 1184940-46-2分式: CHFNO分量: 364.34作靶点: SGK作通路: Metabolic Enzyme/Protease储存式: 4C, sealed storage, away from moisture* In solvent : -80C, 6 months; -20C, 1 month (sealedstorage, away from m

2、oisture)溶解性数据体外实验 DMSO : 100 mg/mL (274.47 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7447 mL 13.7234 mL 27.4469 mL5 mM 0.5489 mL 2.7447 mL 5.4894 mL10 mM 0.2745 mL 1.3723 mL 2.7447 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选

3、择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (7.55 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (7.55 mM); Clea

4、r solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (7.55 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 EMD638683 (S-Form)是SGK1抑制剂，IC50 300 nM。REFERENCES1. Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28(1):137-46.2. Sgk1 inhibitors for the prophylaxis and/or therapy of viral diseases and/or carcinomas US 20110060050 A1McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559