Sarpogrelate-hydrochloride-MCI-9042-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESarpogrelate hydrochlorideCat. No.: HY-10564CAS No.: 135159-51-2Synonyms: MCI-9042分式: CHClNO分量: 465.97作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mont

2、h溶解性数据体外实验 DMSO : 62 mg/mL (133.06 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1461 mL 10.7303 mL 21.4606 mL5 mM 0.4292 mL 2.1461 mL 4.2921 mL10 mM 0.2146 mL 1.0730 mL 2.1461 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配

3、制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.37 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.37 mM); Clear solution1

4、/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.37 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Sarpogrelate hydrochloride (MCI-9042)5-HT2拮抗剂，可作抗板类化合物。户使本产品发表的科研献 Exp Neurol. 2019 Aug 1:113030.See more customer validations on HYPERLINK / www.M

5、edChemEREFERENCES1. Nishio, H., A. Inoue, and Y. Nakata, Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptorsubtypes. Arch Int Pharmacodyn Ther, 1996. 331(2): p. 189-202.2. Pertz, H. and S. Elz, In-vitro pharmacology of sarpogrelate and the enantiome

6、rs of its major metabolite: 5-HT2A receptor specificity,stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. J Pharm Pharmacol, 1995. 47(4): p.310-6.3. Miyazaki, M., et al., Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheralarterial disease. J Cardiovasc Pharmacol, 2007. 49(4): p. 221-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te