KKL-10 - Bacterial 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEKKL-10Cat. No.: HY-101865CAS No.: 952849-76-2分式: CHBrNOS分量: 364.22作靶点: Bacterial作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 6.8 mg/mL (18.67 mM; Need ultrasonic)Mass

2、Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7456 mL 13.7280 mL 27.4559 mL5 mM 0.5491 mL 2.7456 mL 5.4912 mL10 mM 0.2746 mL 1.3728 mL 2.7456 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 KKL-10种具有谱抗 活性的分核糖体拯救抑制剂。体外研究The ribosome rescue inhibitor KKL-10 exhibits exceptional

3、antimicrobial activity against both attenuated andfully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strainLVS and Schu S4 are 0.12 and 0.48 g/mL, respectively. KKL-10 arrests intracellular growth of F. tularensisduring all stages of infection.

4、KKL-10 does not affect macrophage viability or function. KKL-10 producescytotoxic effects of less than 5% at concentrations up to 17.5 g/mL. The combination of IFN- stimulation1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEand KKL-10 activity results in a reduction of the bacterial load by 99.9%.

5、KKL-10 is also able to inhibitgrowth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells 1.REFERENCES1. Goralski TD, et al. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication.Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02