Piracetam-UCB-6215-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPiracetamCat. No.: HY-B0585CAS No.: 7491-74-9Synonyms: UCB-6215分式: CHNO分量: 142.16作靶点: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验

2、DMSO : 100 mg/mL (703.43 mM)H2O : 50 mg/mL (351.72 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 7.0343 mL 35.1716 mL 70.3433 mL5 mM 1.4069 mL 7.0343 mL 14.0687 mL10 mM 0.7034 mL 3.5172 mL 7.0343 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实

3、验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (17.59 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules

4、您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (17.59 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Piracetam (UCB-6215)GABA的环状衍物，可作于多种认知障碍。体外研究 Piracetam (UCB-6215) is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42,in a concentration-dependent manner. Preincubation of pi

5、racetam, at a piracetam/peptide ratio of 960, during20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescentprobes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced bythe peptide in a dose-dependent fashio

6、n (piracetam/peptide ratios from 9.6 to 960) 1.体内研究 Piracetam (UCB-6215) ( 2. Piracetam (UCB-6215) (300 mg/kg daily for 6 weeks) improves active avoidancelearning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in theaged rats. Piracetam (UCB-6215) (30

7、0 mg/kg daily for 6 weeks) also improves NMDA receptor density in thehippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to alesser extent in the hippocampus of rats 3.REFERENCES1. Mingeot-Leclercq, M.P., et al., Piracetam inhibits the lipid-destab

8、ilising effect of the amyloid peptide Abeta C-terminal fragment. BiochimBiophys Acta, 2003. 1609(1): p. 28-38.2. Muller, W.E., et al., Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain. Biochem Pharmacol, 1997.53(2): p. 135-40.3. Scheuer, K., et al., Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain.Pharmacopsychiatry, 1999. 32 Suppl 1: p. 10-6.McePdfHeightCaution: Product has not been fully validated for medical appli