Zaurategrast-ethyl-ester-CDP323-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEZaurategrast ethyl esterCat. No.: HY-75385CAS No.: 455264-30-9Synonyms: CDP323; UCB1184197分式: CHBrNO分量: 549.46作靶点: Integrin作通路: Cytoskeleton储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 1

2、50 mg/mL (273.00 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.55 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.55 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Zaurategrast ethyl este

3、r (CDP323)CT7758 的酯前药 1， 41/47 整联蛋拮抗剂，可于治疗炎症和免疫疾病 2。IC50 & Target 41/47 integrin 1体外研究 Zaurategrast ethyl ester (CDP323), an ethyl ester prodrug of CT7758, shows some improvements inincreasing mass transfer 1.REFERENCES1. Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokineti

4、cs of CT7758, an 41/47 Integrin Antagonist. DrugMetab Dispos. 2015 Sep;43(9):1381-91.2. Davenport RJ, et al. Alpha4-integrin antagonism-an effective approach for the treatment of inflammatory diseases? Drug Discov Today.2007 Jul;12(13-14):569-76.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021