Sumanirole-maleate-U-95666E-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESumanirole maleateCat. No.: HY-70081ACAS No.: 179386-44-8Synonyms: U-95666E; PNU-95666分式: CHNO分量: 319.31作靶点: Dopamine Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、1 month溶解性数据体外实验 DMSO : 50 mg/mL (156.59 mM; Need ultrasonic)H2O : 10 mg/mL (31.32 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1318 mL 15.6588 mL 31.3175 mL5 mM 0.6264 mL 3.1318 mL 6.2635 mL10 mM 0.3132 mL 1.5659 mL 3.1318 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内

3、实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.83 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (

4、7.83 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.83 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 ofabout 46 nM.IC50 val

5、ue: 46 nM (EC50)Target: D2 receptorSumanirole was developed for the treatment ofParkinsons disease and restless leg syndrome. While it has never been approved for medical use.Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanismsthat are based on a do

6、pamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.REFERENCES1. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a SequentialOxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-