Droxinostat-NS-41080-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDroxinostatCat. No.: HY-13267CAS No.: 99873-43-5Synonyms: NS 41080分式: CHClNO分量: 243.69作靶点: HDAC作通路: Cell Cycle/DNA Damage; Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/

2、mL (615.54 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.1036 mL 20.5179 mL 41.0357 mL5 mM 0.8207 mL 4.1036 mL 8.2071 mL10 mM 0.4104 mL 2.0518 mL 4.1036 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Droxinostat(NS41080)是HDAC3，H

3、DAC6和HDAC8抑制剂，IC50分别为16.9，2.47和1.46 M。IC50 & Target HDAC8 HDAC6 HDAC31.46 M (IC50) 2.47 M (IC50) 16.9 M (IC50)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE户使本产品发表的科研献 J Mol Med (Berl). 2019 Jun 14.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Liu J, et al. Droxinostat, a

4、Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of theMitochondrial Pathway and Downregulation of FLIP. Transl Oncol. 2016 Feb;9(1):70-8.2. Wood TE et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor

5、ligands. Mol Cancer Ther. 2010Jan;9(1):246-56.3. MMcCourt C, Maxwell P, Mazzucchelli R, Montironi R, Scarpelli M, Salto-Tellez M, OSullivan JM, Longley DB, Waugh DJ.,Elevation ofc-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor-Targeted Therapy.,Clin

6、CancerRes. 2012 Jul 15;18(14):3822-33. Epub 2012 May 234. Bijangi-Vishehsaraei K, Saadatzadeh MR, Huang S, Murphy MP, Safa AR.,4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH)targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.,Mol Cell Biochem. 2010 Se

7、p;342(1-2):133-42. Epub 2010 May 6.5. Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y, MacLean N, Ketela T,Reed JC, Moffat J, Minden MD, Batey RA, Schimmer AD.,Selective inhibition of histone deacetylases sensitizes malignant cells to deathreceptor ligands.,Mol Cancer Ther. 2010 Jan;9(1):246-56. Epub 2010 Jan 6.McePdfHeightCaution: Product has not been fully validated for medical applications.For resear