Cefdinir-FK-482-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECefdinirCat. No.: HY-B0136CAS No.: 91832-40-5Synonyms: FK-482; CI-983分式: CHNOS分量: 395.41作靶点: Bacterial作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 33.33 mg/mL (84.29 m

2、M; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.32 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.32 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5

3、 mg/mL (6.32 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Cefdinir (FK-482)半合成谱抗菌剂。IC50 & Target Antibacterial 1.体外研究 Cefdinir (FK-482) is a third generation oral cephalosporin antibiotic. Cefdinir (Omnicef) is a semi-synthetic,broad-spectrum antibiotic in the third generation of the cephalosporin clas

4、s, which is proved to be effectivefor common bacterial infections of the ear, sinus, throat, and skin. It can be used to treat infections caused byseveral Gram-negative and Gram-positive bacteria. It is available in US as Omnicef by Abbott Laboratoriesand in India as Cednir by Abbott, Kefnir by Glen

5、mark and Cefdiel by Ranbaxy. As of 2008, cefdinir was thehighest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales ofits generic versions alone 1. Cefdinir (FK-482), a new oral 2-amino-5-thiazolyl cephalosporin, inhibited theluminol-amplified chemil

6、uminescence (LACL) response of human neutrophils stimulated by PMA but notopsonized zymosan, in a concentration-dependent but not time-dependent manner. The LACL response toopsonized zymosan in cytochalasin B-treated neutrophils was, however, inhibited by cefdinir. Furthermore,cefdinir inhibited LAC

7、L generation in cell-free systems consisting of H2O2, NaI, and either horseradishperoxidase or a myeloperoxidase-containing neutrophil extract. Orthodianisidine oxidation in these twoacellular systems was inhibited by cefdinir 2.REFERENCES1. Soejima R. Cefdinir. Jpn J Antibiot. 1992 Oct;45(10):1239-

8、52.2. Labro MT, et al. Cefdinir (CI-983), a new oral amino-2-thiazolyl cephalosporin, inhibits human neutrophil myeloperoxidase in theextracellular medium but not the phagolysosome. J Immunol. 1994 Mar 1;152(5):2447-55.McePdfHeightCaution: Product has not been fully validated for medical applications.For