SGN-2FF _Fucosylation 抑制剂- MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESGN-2FFCat. No.: HY-107366CAS No.: 2089647-47-0分式: CHFO分量: 166.15作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 36.67 mg/mL (220.70 mM; Need ultrasonic)Mass Solvent1 m

2、g 5 mg 10 mg Concentration制备储备液1 mM 6.0187 mL 30.0933 mL 60.1866 mL5 mM 1.2037 mL 6.0187 mL 12.0373 mL10 mM 0.6019 mL 3.0093 mL 6.0187 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 SGN-2FF种可服的岩藻糖基化抑制剂，直接抑制岩藻糖基转移酶 (fucosyltransferase) 的活性，具有抗肿瘤活性。IC50 & Target Fucosyltransferas

3、e 1体外研究SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting thefucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEproduction of afucosylated glycoprotein

4、s including antibodies. SGN-2FF activates human T cells in anantigen-dependent manner 1.体内研究 SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growthdelay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model 1.REFERENCES

5、1. Stephen C. Alley, et al. Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activitythrough multiple immune mechanisms. Cancer Res 2017;77(13 Suppl).McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895