Febuxostat-TEI-6720-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFebuxostatCat. No.: HY-14268CAS No.: 144060-53-7Synonyms: TEI 6720; TMX 67分式: CHNOS分量: 316.37作靶点: Xanthine Oxidase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO

2、 : 50 mg/mL (158.04 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1609 mL 15.8043 mL 31.6086 mL5 mM 0.6322 mL 3.1609 mL 6.3217 mL10 mM 0.3161 mL 1.5804 mL 3.1609 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实

3、验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.90 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Febuxostat(TEI 6720;TMX 67 )是选择性黄嘌呤氧化酶（XO）抑制剂，Ki为0.6 nM。户使本产品发表的科研献 Harvard Medical

4、 School LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Takano Y, et al. Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Life Sci, 2005,76(16), 1835-1847.2. Snchez-Lozada LG, et al. Effects of febuxostat on metabo

5、lic and renal alterations in rats with fructose-induced metabolic syndrome.Am J Physiol Renal Physiol, 2008, 294(4), F710-F718.3. Snchez-Lozada LG, et al. Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and withouthyperuricemia. Nephron Physiol, 2008, 108(4), p6

6、9-p78.4. Xu X, et al. Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunctionin mice. Card Fail, 2008, 14(9), 746-753.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820