Leu-AMS _Bacterial 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELeu-AMSCat. No.: HY-108900CAS No.: 288591-93-5分式: CHNOS分量: 459.48作靶点: Bacterial; Aminoacyl-tRNA Synthetase作通路: Anti-infection; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体

2、外实验 DMSO : 49.17 mg/mL (107.01 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1764 mL 10.8819 mL 21.7637 mL5 mM 0.4353 mL 2.1764 mL 4.3527 mL10 mM 0.2176 mL 1.0882 mL 2.1764 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Leu-AMS亮

3、氨酰-tRNA 合成酶 (LRS) 的有效抑制剂，其 IC50 值为 22.34 nM 且能够抑制细 的长。IC50 & Target IC50: 22.34 nM (LRS) 1体外研究Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM.Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase

4、 (S6K)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEphosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-inducedmTORC1 activation 1.REFERENCES1. Yoon S, et al. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-TargetedMammalian Target ofRapamycin Complex 1 (mTORC1) Inhibitors. J Med Chem. 2016 Nov 23;59(22):10322-10328.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;