Proton-Pump-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html Proton HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html PumpProton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms areb

2、ased on conformational changes of the protein structure or on theQ cycle. In cell respiration, the proton pump uses energy totransport protons from the matrix of the mitochondrion to the inter-membrane space. It is an active pump, that generates aprotonconcentration gradient across the inner mitocho

3、ndrial membrane, because there are more protons outside the matrix thaninside. The difference in pH and electric charge (ignoring differences inbuffer capacity) creates an electrochemical potentialdifference that works similar to that of a battery or energy storing unit for the cell. The process cou

4、ld also be seen as analogous tocycling uphill or charging a battery for later use, as it produces potential energy. The proton pump does not create energy, butforms a gradient that stores energy for later use.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html Proton HYPERLINK http

5、s:/www.MedChemE/Targets/Proton Pump.html HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html Pump HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html HYPERLINK https:/www.M

6、edChemE/Targets/Proton Pump.html Antagonists HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html & HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html HYPERLINK https:/www.MedChemE/Targets/Proton Pump.html Activators HYPERLINK https:/www.M

7、edChemE/_R_-Lansoprazole.html (R)-Lansoprazole(Dexlansoprazole) Cat. No.: HY-13662B HYPERLINK https:/www.MedChemE/r-lansoprazole-d4.html (R)-Lansoprazole-d4(Dexlansoprazole-d4) Cat. No.: HY-13662BS(R)-Lansoprazole is the R enantiomer ofLansoprazole, Lansoprazole (AG 1749) is an orallyactive proton p

8、ump inhibitor which prevents thestomach from producing acid.(R)-Lansoprazole-d4 is deuterium labeled(R)-Lansoprazole. (R)-Lansoprazole is the Renantiomer of Lansoprazole, Lansoprazole (AG 1749)is an orally active proton pump inhibitor whichprevents the stomach from producing acid.Purity: 95.04%Clini

9、cal Data: LaunchedSize: 10 mM 1 mL, 100 mg, 500 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/racemic-vasicine.html ()-Vasicine()-Peganine) Cat. No.: HY-N7031 HYPERLINK https:/www.MedChemE/5-hydroxylansoprazole.html 5-Hydroxylansoprazole(AG1908) Ca

10、t. No.: HY-118283()-Vasicine is the racemate of Vasicine. Vasicine(Peganine) significantly inhibits H+-K+-ATPaseactivity in vitro with an IC of5073.47 g/mL. Anti-ulcer activity. Vasicineshows significant anti-secretory, antioxidantand cytoprotective effect.5-Hydroxylansoprazole (AG1908) is an active

11、metabolite of Lansoprazole in plasma. Lansoprazoleis metabolized by CYP2C19 forming5-Hydroxylansoprazole. Lansoprazole is a gastricproton-pump inhibitor and is effective in thetreatment of various peptic diseases.Purity: 99.0%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 98%Clinical

12、 Data: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/abeprazan.html Abeprazan(DWP14012; Fexuprazan) Cat. No.: HY-109079 HYPERLINK https:/www.MedChemE/abeprazan-hydrochloride.html Abeprazan HYPERLINK https:/www.MedChemE/abeprazan-hydrochloride.html HYPERLINK https:/www.MedChemE/abep

13、razan-hydrochloride.html hydrochloride(DWP14012 hydrochloride; Fexuprazan hydrochloride) Cat. No.: HY-109079AAbeprazan (DWP14012) is a potassium-competitiveacid blocker. Abeprazan inhibits H+, K+- ATPaseby reversible potassium-competitive ionic bindingwith no acid activation required.Abeprazan hydro

14、chloride (DWP14012 hydrochloride)is a potassium-competitive acid blocker.Abeprazan hydrochloride inhibits H+, K+- ATPaseby reversible potassium-competitive ionic bindingwith no acid activation required.Purity: 99.58%Clinical Data: Phase 3Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Dat

15、a: Phase 3Size: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/abscisic-acid.html Abscisic HYPERLINK https:/www.MedChemE/abscisic-acid.html HYPERLINK https:/www.MedChemE/abscisic-acid.html acid HYPERLINK https:/www.MedChemE/abscisic-acid.html HYPERLINK https:/www.MedChemE/Bafilomycin_A1.html Bafilomycin H

16、YPERLINK https:/www.MedChemE/Bafilomycin_A1.html HYPERLINK https:/www.MedChemE/Bafilomycin_A1.html A1(S)-(+)-Abscisic acid; ABA) Cat. No.: HY-100560Cat. No.: HY-100558Abscisic acid (S)-(+)-Abscisic acid), an orallyactive phytohormone in fruits and vegetables, isan endogenously produced mammalian hor

17、mone.Abscisic acid is a growth inhibitor and canregulate many aspects of plant growth anddevelopment.Bafilomycin A1 is a specific and reversibleinhibitor of vacuolar H+-ATPase (V-ATPase) withIC values of 4-400 nmol/mg. Bafilomycin A1, a50macrolide antibiotic, is also used as anautophagy inhibitor at

18、 the late stage.Purity: 99.88%Clinical Data: Phase 4Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 99.43%Clinical Data: No Development ReportedSize: 100 g, 500 g, 1 mg, 5 mg HYPERLINK https:/www.MedChemE/caloxin-2a1.html Caloxin HYPERLINK https:/www.MedChemE/caloxin-2a1.html HYPERLINK https:/www.MedChe

19、mE/caloxin-2a1.html 2A1 HYPERLINK https:/www.MedChemE/caloxin-2a1.html HYPERLINK https:/www.MedChemE/caloxin-2a1-tfa.html Caloxin HYPERLINK https:/www.MedChemE/caloxin-2a1-tfa.html HYPERLINK https:/www.MedChemE/caloxin-2a1-tfa.html 2A1 HYPERLINK https:/www.MedChemE/caloxin-2a1-tfa.html HYPERLINK htt

20、ps:/www.MedChemE/caloxin-2a1-tfa.html TFACat. No.: HY-P3278 Cat. No.: HY-P3278ACaloxin 2A1 is an extracellular plasma membraneCa2+-ATPase (PMCA) peptide inhibitor. Caloxin2A1 does not affect basal Mg2+-ATPase orNa+-K+-ATPase.Caloxin 2A1 TFA is an extracellular plasmamembrane Ca2+-ATPase (PMCA) pepti

21、de inhibitor.Caloxin 2A1 TFA does not affect basalMg2+-ATPase or Na+-K+-ATPase.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.69%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLIN

22、K https:/www.MedChemE/Chebulinic-acid.html Chebulinic HYPERLINK https:/www.MedChemE/Chebulinic-acid.html HYPERLINK https:/www.MedChemE/Chebulinic-acid.html acidCat. No.: HY-N2033 HYPERLINK https:/www.MedChemE/concanamycin-a.html Concanamycin HYPERLINK https:/www.MedChemE/concanamycin-a.html HYPERLIN

23、K https:/www.MedChemE/concanamycin-a.html A(Antibiotic X 4357B; Concanamycin; X 4357B) Cat. No.: HY-N1724Chebulinic acid is a potent natural inhibitor ofM. tuberculosis DNA gyrase, also can inhibitSMAD-3 phosphorylation, inhibit H+ K+-ATPaseactivity.Concanamycin A (Antibiotic X 4357B) is a macrolide

24、antibiotic and a specific vacuolar type H+-ATPase(V-ATPase) inhibitor.Purity: 99.42%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mgPurity: 97.84%Clinical Data: No Development ReportedSize: 25 g, 50 g HYPERLINK https:/www.MedChemE/diphyllin.html Diphyllin HYPERLINK https:/www.MedC

25、hemE/diphyllin.html HYPERLINK https:/www.MedChemE/en6.html EN6Cat. No.: HY-N2532 Cat. No.: HY-128892Diphyllin is an arylnaphthalene lignan isolatedfrom Justicia procumbens and is a potent HIV-1inhibitor with an IC50 of 0.38 M. Diphyllin isactive against vesicular stomatitis virus (VSV)and influenza

26、virus.EN6 is a small-molecule in vivo activator ofautophagy that covalently targets cysteine 277 inthe ATP6V1A subunit of the lysosomal the vacuolarH+ ATPase (v-ATPase).Purity: 99.85%Clinical Data: No Development ReportedSize: 10 mg, 25 mgPurity: 99.16%Clinical Data:Size: 10 mM 1 mL, 1 mg, 5 mg, 10

27、mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Esomeprazole_magnesium.html Esomeprazole HYPERLINK https:/www.MedChemE/Esomeprazole_magnesium.html HYPERLINK https:/www.MedChemE/Esomeprazole_magnesium.html magnesium(S)-Omeprazole magnesium; (-)-Omeprazole magnesium) Cat. No.: HY-B1446 HYPERLINK https

28、:/www.MedChemE/esomeprazole-magnesium-salt.html Esomeprazole HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-salt.html HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-salt.html magnesium HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-salt.html HYPERLINK https:/www.MedChemE/esomeprazo

29、le-magnesium-salt.html salt HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-salt.html (S)-Omeprazole magnesium salt;(-)-Omeprazole magnesium salt) Cat. No.: HY-17021AEsomeprazole magnesium (S)-Omeprazole magnesium)is a potent and orally active H+, K+-ATPaseinhibitor. Esomeprazole magnesium has

30、thepotential for upper intestinal disorders andgastroesophageal reflux disease research.Esomeprazole magnesium salt (S)-Omeprazolemagnesium salt) is a potent and orally activeproton pump inhibitor and reduces acid secretionthrough inhibition of the H+, K+-ATPase ingastric parietal cells.Purity: 98.0

31、%Clinical Data: LaunchedSize: 10 mM 1 mL, 50 mgPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-trihydrate.html Esomeprazole HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-trihydrate.html HYPERLINK https:/www.MedChemE/esomeprazole-magnesiu

32、m-trihydrate.html magnesium HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-trihydrate.html HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-trihydrate.html trihydrate HYPERLINK https:/www.MedChemE/esomeprazole-magnesium-trihydrate.html (S)-Omeprazole magnesium HYPERLINK https:/www.MedChemE

33、/Esomeprazole-potassium-salt.html Esomeprazole HYPERLINK https:/www.MedChemE/Esomeprazole-potassium-salt.html HYPERLINK https:/www.MedChemE/Esomeprazole-potassium-salt.html potassium HYPERLINK https:/www.MedChemE/Esomeprazole-potassium-salt.html HYPERLINK https:/www.MedChemE/Esomeprazole-potassium-s

34、alt.html salt HYPERLINK https:/www.MedChemE/Esomeprazole-potassium-salt.html (S)-Omeprazole potassium salt;trihydrate; (-)-Omeprazole magnesium trihydrate) Cat. No.: HY-17022 (-)-Omeprazole potassium salt) Cat. No.: HY-17021BEsomeprazole magnesium trihydrate (S)-Omeprazolemagnesium trihydrate) is a

35、potent and orallyactive H+, K+-ATPase inhibitor. Esomeprazolemagnesium trihydrate has the potential for upperintestinal disorders and gastroesophageal refluxdisease research.Esomeprazole potassium salt (S)-Omeprazolepotassium salt) is a potent and orally activeproton pump inhibitor and reduces acid

36、secretionthrough inhibition of the H+, K+-ATPase ingastric parietal cells.Purity: 95.79%Clinical Data: LaunchedSize: 50 mg, 100 mg, 200 mg, 500 mgPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Esomeprazole-sodium.html Esomeprazole HYPERLINK https:/www.MedChemE/Esome

37、prazole-sodium.html HYPERLINK https:/www.MedChemE/Esomeprazole-sodium.html sodium HYPERLINK https:/www.MedChemE/Esomeprazole-sodium.html HYPERLINK https:/www.MedChemE/esomeprazole-d3.html Esomeprazole-d3(S)-Omeprazole sodium; (-)-Omeprazole sodium) Cat. No.: HY-17023Cat. No.: HY-17021S1Esomeprazole

38、sodium (S)-Omeprazole sodium) is apotent and orally active proton pumpinhibitor. Esomeprazole reduces acid secretionthrough inhibition of the H+, K+-ATPase ingastric parietal cells.Esomeprazole-d3 is deuterium labeled Esomeprazole.Esomeprazole (S)-Omeprazole) is a potent andorally active proton pump

39、 inhibitor and reducesacid secretion through inhibition of the H+,K+-ATPase in gastric parietal cells.Purity: 99.80%Clinical Data: LaunchedSize: 10 mg, 50 mg, 100 mg, 250 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/esomeprazole-d3-s

40、odium.html Esomeprazole-d3 HYPERLINK https:/www.MedChemE/esomeprazole-d3-sodium.html HYPERLINK https:/www.MedChemE/esomeprazole-d3-sodium.html sodiumCat. No.: HY-17021S HYPERLINK https:/www.MedChemE/Ilaprazole.html Ilaprazole(IY-81149) Cat. No.: HY-101664Esomeprazole-d3 sodium is the deuterium label

41、edEsomeprazole. Esomeprazole (S)-Omeprazole) is apotent and orally active proton pump inhibitor andreduces acid secretion through inhibition of theH+, K+-ATPase in gastric parietal cells.Ilaprazole (IY-81149) is an orally active protonpump inhibitor. Ilaprazole irreversiblyinhibits H+/K+-ATPase in a

42、 dose-dependentmanner with an IC of pump inhibitory activity of506 M in rabbit parietal cell preparation.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: LaunchedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/ilaprazole-sodi

43、um.html Ilaprazole HYPERLINK https:/www.MedChemE/ilaprazole-sodium.html HYPERLINK https:/www.MedChemE/ilaprazole-sodium.html sodium(IY-81149 sodium) Cat. No.: HY-B2145 HYPERLINK https:/www.MedChemE/km91104.html KM91104Cat. No.: HY-135474Ilaprazole (IY-81149) sodium is an orally activeproton pump inh

44、ibitor. Ilaprazole sodiumirreversibly inhibits H+/K+-ATPase in adose-dependent manner with an IC of 6 M in50rabbit parietal cell preparation.KM91104, a cell-permeable V-ATPase inhibitor,specifically targets the a3-b2 subunits ofV-ATPase.Purity: 98.50%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10

45、 mg, 25 mg, 50 mg, 100 mgPurity: 99.64%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/lansoprazole.html Lansoprazole(AG-1749) Cat. No.: HY-13662 HYPERLINK https:/www.MedChemE/lansoprazole-sulfide-d4.html Lansoprazole HYPERLINK https:/www.MedChemE

46、/lansoprazole-sulfide-d4.html HYPERLINK https:/www.MedChemE/lansoprazole-sulfide-d4.html Sulfide HYPERLINK https:/www.MedChemE/lansoprazole-sulfide-d4.html HYPERLINK https:/www.MedChemE/lansoprazole-sulfide-d4.html D4Cat. No.: HY-W013186SLansoprazole (AG 1749) is an orally active protonpump inhibito

47、r which prevents the stomach fromproducing acid. Lansoprazole (AG 1749) is a potentbrain penetrant neutral sphingomyelinase(N-SMase) inhibitor (exosome inhibitor).Lansoprazole Sulfide D4 is a deuterium labeledLansoprazole Sulfide. Lansoprazole Sulfide is anactive metabolite of the proton pump inhibi

48、torLansoprazole.Purity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g, 5 gPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/lansoprazole-d4.html Lansoprazole-d4 HYPERLINK https:/www.MedChemE/lansoprazole-d4.html HYPERLINK https:/www.MedChemE/

49、AZD0865.html Linaprazan(AG-1749-d4) Cat. No.: HY-13662S (AZD0865) Cat. No.: HY-100412Lansoprazole D4 (AG-1749 D4) is a deuteriumlabeled Lansoprazole. Lansoprazole is a protonpump inhibitor which prevents the stomach fromproducing acid.Linaprazan (AZD0865) inhibits gastric H+,K+-ATPaseby K+-competiti

50、ve binding. (IC50: 1.0 0.2 M) Itis a acid-suppressing agents with rapid onset ofaction and potent acid inhibition. In vitro:Linaprazan can inhibit the final step in acidsecretion.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98.80%Clinical Data: Phase 2Size: 10 mM 1

51、 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/manzamine-a-hydrochloride.html Manzamine HYPERLINK https:/www.MedChemE/manzamine-a-hydrochloride.html HYPERLINK https:/www.MedChemE/manzamine-a-hydrochloride.html A HYPERLINK https:/www.MedChemE/manzamine-a-hydrochloride.html HYPER

52、LINK https:/www.MedChemE/manzamine-a-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/manzamine-a-hydrochloride.html HYPERLINK https:/www.MedChemE/Omeprazole.html OmeprazoleCat. No.: HY-117025A(H 16868) Cat. No.: HY-B0113Manzamine A hydrochloride, an orally activebeta-carboline alkaloi

53、d, inhibits specificallyGSK-3 and CDK-5 with IC s of 10.2 M and 1.550M, respectively. Manzamine A hydrochloridetargets vacuolar ATPases and inhibits autophagyin pancreatic cancer cells.Omeprazole (H 16868), a proton pump inhibitor(PPI), is available for treatment of acid-relatedgastrointestinal diso

54、rders. Omeprazole showscompetitive inhibition of CYP2C19 activity with aK of 2 to 6 M.iPurity: 99.29%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.19%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 500 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/

55、www.MedChemE/omeprazole-sodium.html Omeprazole HYPERLINK https:/www.MedChemE/omeprazole-sodium.html HYPERLINK https:/www.MedChemE/omeprazole-sodium.html sodium(H 16868 sodium) Cat. No.: HY-B0113A HYPERLINK https:/www.MedChemE/omeprazole-13cd3.html Omeprazole-13CD3(H 16868-13CD3) Cat. No.: HY-B0113S3

56、Omeprazole sodium (H 16868 sodium), a protonpump inhibitor (PPI), is available fortreatment of acid-related gastrointestinaldisorders. Omeprazole sodium shows competitiveinhibition of CYP2C19 activity with a K of 2 toi6 M.Omeprazole-13CD3 (H 16868-13CD3) is a 13C-labeledand deuterium labeled Omepraz

57、ole. Omeprazole (H16868), a proton pump inhibitor (PPI), isavailable for treatment of acid-relatedgastrointestinal disorders.Purity: 98.03%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 500 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/Ome

58、prazole-D3.html Omeprazole-d3(H 16868-d3) Cat. No.: HY-B0113S HYPERLINK https:/www.MedChemE/omeprazole-d3-1.html Omeprazole-d3-1(H 16868-d3-1) Cat. No.: HY-B0113S1Omeprazole D3 (H 16868 D3) is deuterium labeledOmeprazole. Omeprazole, a proton pumpinhibitor (PPI), is available for treatment ofacid-re

59、lated gastrointestinal disorders.Omeprazole-d3-1 (H 16868-d3-1) is the deuteriumlabeled Omeprazole. Omeprazole (H 16868), aproton pump inhibitor (PPI), is available fortreatment of acid-related gastrointestinaldisorders.Purity: 98.99%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurit

60、y: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/pantoprazole.html Pantoprazole(BY1023; SKF96022) Cat. No.: HY-17507 HYPERLINK https:/www.MedChemE/Pantoprazole-sodium.html Pantoprazole HYPERLINK https:/www.MedChemE/Pantoprazole-sodium.html HYPERLINK h